This database contains 10 studies, archived under the term: "cognitive function"
No effect of donepezil on striatal dopamine release in mild to moderate Alzheimer’s disease
Objective: Work in experimental animals suggests that an interaction with dopaminergic networks might explain some of the therapeutic effects of the cholinesterase inhibitor class of drugs. This study aimed to test whether acute (single 5 mg) or 4–8 weeks (5–10 mg) of treatment with oral donepezil would elicit measurable striatal dopamine (DA) release in patients […]
Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: A randomized trial
Lautenschlager, Nicola T.,
Cox, Kay L.,
Flicker, Leon,
Foster, Jonathan K.,
van Bockxmeer, Frank M.,
Xiao, Jianguo,
Greenop, Kathryn R.,
Almeida, Osvaldo P.
Context: Many observational studies have shown that physical activity reduces the risk of cognitive decline; however, evidence from randomized trials is lacking. Objective: To determine whether physical activity reduces the rate of cognitive decline among older adults at risk. Design and Setting: Randomized controlled trial of a 24-week physical activity intervention conducted between 2004 and […]
The impact of supplemental macular carotenoids in Alzheimer’s disease: A randomized clinical trial
Nolan, John M.,
Loskutova, Ekaterina,
Howard, Alan,
Mulcahy, Riona,
Moran, Rachel,
Stack, Jim,
Bolger, Maggie,
Coen, Robert F.,
Dennison, Jessica,
Akuffo, Kwadwo Owusu,
Owens, Niamh,
Power, Rebecca,
Thurnham, David,
Beatty, Stephen
Background: Patients with Alzheimer’s disease (AD) exhibit significantly less macular pigment (MP) and poorer vision when compared to control subjects. Objective: To investigate supplementation with the macular carotenoids on MP, vision, and cognitive function in patients with AD versus controls. Methods: A randomized, double-blind clinical trial with placebo and active arms. 31 AD patients and […]
Long-term metformin usage and cognitive function among older adults with diabetes
Ng, Tze Pin,
Feng, Liang,
Yap, Keng Bee,
Lee, Tih Shih,
Tan, Chay Hoon,
Winblad, Bengt
Evidence strongly supports the important role of insulin resistance in cognitive decline and dementia and suggests that insulin sensitizers may protect against cognitive decline in diabetic and pre-diabetic individuals. Inconclusive results have been reported in clinical trials of rosiglitazone, an insulin sensitizer that also increases cardiovascular mortality risks. No study has yet reported a protective […]
Encouraging lifestyle behaviour change in mild cognitive impairment patients: Development of appropriate educational material
Neville, Charlotte E.,
McCourt, Hannah J.,
McKinley, Michelle C.,
Lowis, Carole,
Barrett, Suzanne L.,
McGuinness, Bernadette,
Todd, Stephen,
Lawlor, Brian,
Gibb, Matthew,
Coen, Robert F.,
Passmore, Anthony P.,
Woodside, Jayne V.
Objectives: A healthy lifestyle may help maintain cognitive function and reduce the risk of developing dementia. This study employed a focus group approach in order to gain insight into opinions of mild cognitive impairment (MCI) patients, caregivers (CG) and health professionals (HP) regarding lifestyle and its relationship with cognition. The qualitative data were used to […]
Can a memory club help maintain cognitive function? A pilot investigation
Fritsch, Thomas,
McClendon, McKee J.,
Wallendal, Maggie S.,
Smyth, Kathleen A.,
Geldmacher, David S.,
Hyde, Trevor F.,
Leo, Gary J.
In a pilot investigation we evaluated the impact of a structured early memory loss (EML) program intervention in a longitudinal (repeated measures) study of 55 persons with mild cognitive impairment or mild dementia. At four test sites we examined whether participation in the club—which sought to stimulate mental activity and social interaction, provide opportunities for […]
The impact of group music therapy on depression and cognition in elderly persons with dementia: a randomized controlled study
Chu, H.,
Yang, C.-Y.,
Lin, Y.,
Ou, K.-L.,
Lee, T.-Y.,
O'Brien, A. P.,
Chou, K.-R.
Objective: The aims of this study were to determine the effectiveness of group music therapy for improving depression and delaying the deterioration of cognitive functions in elderly persons with dementia.; Method: The study had a prospective, parallel-group design with permuted-block randomization. Older persons with dementia (N = 104) were randomly assigned to the experimental or […]