ten Brinke, Lisanne F., Bolandzadeh, Niousha, Nagamatsu, Lindsay S., Hsu, Chun Liang, Davis, Jennifer C., Miran-Khan, Karim, Liu-Ambrose, Teresa

Background: Mild cognitive impairment (MCI) is a well-recognised risk factor for dementia and represents a vital opportunity for intervening. Exercise is a promising strategy for combating cognitive decline by improving brain structure and function. Specifically, aerobic training (AT) improved spatial memory and hippocampal volume in healthy community-dwelling older adults. In older women with probable MCI, […]

Padala, Kalpana P., Padala, Prasad R., McNeilly, Dennis P., Geske, Jenenne A., Sullivan, Dennis H., Potter, Jane F.

Background: Statins are well-known for their cardiovascular benefits. However, the cognitive effects of statins are not well understood. We hypothesized that individuals with preexisting dementia would be more vulnerable to statin-related cognitive effects.; Objective: The aim of this study was to evaluate the impact on cognition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (statin) discontinuation and rechallenge […]

Rodriguez-Sánchez, Emiliano, Criado-Gutiérrez, José, Mora-Simón, Sara, Muriel-Diaz, M, Gómez-Marcos, Manuel A, Recio-Rodríguez, José I, Patino-Alonso, M, Valero-Juan, Luis F, Maderuelo-Fernandez, José A, García-Ortiz, Luis

Background: The aging of the population has led to the increase of chronic diseases, especially dementia and cardiovascular diseases, and it has become necessary for their relatives to dedicate more time in caregiving.The objective in the first phase of this study is to evaluate the effectiveness of a Primary Health Care procedure to increase the […]

Anderson, Craig, Teo, Koon, Gao, Peggy, Arima, Hisatomi, Dans, Antonio, Unger, Thomas, Commerford, Patrick, Dyal, Leanne, Schumacher, Helmut, Pogue, Janice, Paolasso, Ernesto, Holwerda, Nicolaas, Chazova, Irina, Binbrek, Azan, Young, James, Yusuf, Salim

Background: cardiovascular risk factors are associated with dementia and cognitive decline. We investigated the effects of renin-angiotensin system blockade on cognitive function in patients aged 55 years and older with established atherosclerotic cardiovascular disease or diabetes with end-organ damage in two clinical trials.; Methods: in the main study, ONTARGET, a double-blind, double-dummy, randomised controlled trial, […]