Li, Wei, Zhang, Jie-Wen, Lu, Fen, Ma, Ming-Ming, Wang, Jiang-qiao, Suo, Ai-Qin, Bai, Ying-ying, Liu, Hui-qin

Objective: To explore the effects of telmisartan, an angiotensin II type 1 receptor blocker with peroxisome proliferator-activated receptor γ-stimulating activity, on the levels of Aβ1-42, interleukin-1β (IL-1β), tumor necrosis factor-alpha (TNF-α) and cognition in elderly hypertensive patients with Alzheimer’s disease (AD).; Methods: A total of 48 patients with probable AD and essential hypertension were randomly […]

Kennelly, Sean, Abdullah, Laila, Kenny, Rose Anne, Mathura, Venkat, Luis, Cheryl A., Mouzon, Benoit, Crawford, Fiona, Mullan, Michael, Lawlor, Brian

Background: Evidence suggests that dihydropyridine calcium channel blockers may be useful in preventing and treating Alzheimer’s disease (AD).; Objective: In an open-label trial of safety and tolerability of nilvadipine in patients with AD, we examined cognition and executive function over a short time period to determine an influence of nilvadipine on these outcomes.; Method: We […]

Peters, Ruth, Beckett, Nigel, Forette, Francoise, Tuomilehto, Jaakko, Ritchie, Craig, Walton, Ivan, Waldman, Adam, Clarke, Robert, Poulter, Ruth, Fletcher, Astrid, Bulpitt, Christopher

Background: It is well known that the global population is aging and that those over the age of 80 are the fastest growing part of this expansion. Also known is that prevalence of hypertension and cognitive decline both increase with increasing age.; Method: The Hypertension in the Very Elderly Trial (HYVET) was a double blind […]

Louis, Elan D., Benito-León, Julián, Bermejo-Pareja, Félix

Background: Recent interest in antihypertensive agents, especially calcium channel blockers, has been sparked by the notion that these medications may be neuroprotective. A modest literature, with mixed results, has examined whether these medications might lower the odds or risk of Parkinson’s disease (PD) or dementia. There are no data for essential tremor (ET).; Objective: To […]

Williamson, Jeff D., Launer, Lenore J., Bryan, R. Nick, Coker, Laura H., Lazar, Ronald M., Gerstein, Hertzel C., Murray, Anne M., Sullivan, Mark D., Horowitz, Karen R., Ding, Jingzhong, Marcovina, Santica, Lovato, Laura, Lovato, James, Margolis, Karen L., Davatzikos, Christos, Barzilay, Joshua, Ginsberg, Henry N., Linz, Peter E., Miller, Michael E.

Importance: Persons with type 2 diabetes mellitus (T2DM) are at increased risk for decline in cognitive function, reduced brain volume, and increased white matter lesions in the brain. Poor control of blood pressure (BP) and lipid levels are risk factors for T2DM-related cognitive decline, but the effect of intensive treatment on brain function and structure […]

Peters, Ruth, Beckett, Nigel, Fagard, Robert, Thijs, Lutgarde, Wang, Ji-Guang, Forette, Francoise, Pereira, Lisa, Fletcher, Astrid, Bulpitt, Christopher

Objectives: High blood pressure (BP) has been associated with increased risk of dementia. Concerns have been raised about lowering BP too far in the very elderly and thereby increasing risk. There is some evidence to suggest a potential ‘J’-shaped relationship between DBP and risk of cognitive impairment. This was investigated using data from the HYpertension […]

Kennelly, S. P., Abdullah, L., Paris, D., Parish, J., Mathura, V., Mullan, M., Crawford, F., Lawlor, B. A., Kenny, R. A.

Background: Nilvadipine may lower rates of conversion from mild-cognitive impairment to Alzheimer’s disease (AD), in hypertensive patients. However, it remains to be determined whether treatment with nilvadipine is safe in AD patients, given the higher incidence of orthostatic hypotension (OH) in this population, who may be more likely to suffer from symptoms associated with the […]