This database contains 102 studies, archived under the term: "alzheimer’s disease"
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An open-label, nonplacebo-controlled study on Cistanche tubulosa glycoside capsules (Memoregain(®)) for treating moderate Alzheimer’s Disease
Guo, Qihao,
Zhou, Yan,
Wang, Chao-Jih,
Huang, Young-Ming,
Lee, Yi-Ta,
Su, Muh-Hwan,
Lu, Jiahong
Aim: Efficacy and safety of Cistanche tubulosa glycoside capsules (CTG capsule, Memoregain(®)) for treating Alzheimer’s disease (AD) were studied.; Methods: A total of 18 patients with AD administered with Memoregain(®) for 48 weeks were assessed for drug efficacy by Alzheimer’s Disease Assessment Scale-cognitive subscale (ADAS-cog), Mini-Mental State Examination (MMSE), Activities of Daily Living (ADLs), Blessed […]
Donepezil treatment of older adults with cognitive impairment and depression (DOTCODE study): clinical rationale and design
Pelton, Gregory H.,
Andrews, Howard,
Roose, Steven P.,
Marcus, Sue M.,
D'Antonio, Kristina,
Husn, Hala,
Petrella, Jeffrey R.,
Zannas, Anthony S.,
Doraiswamy, P. Murali,
Devanand, D. P.
Treatment strategies for patients with depression and cognitive impairment (DEP-CI), who are at high risk to develop a clinical diagnosis of dementia, are not established. This issue is addressed in the donepezil treatment of cognitive impairment and depression (DOTCODE) pilot clinical trial. The DOTCODE study is the first long-term treatment trial that assesses differences in […]
Vitamin E and memantine in Alzheimer’s disease: clinical trial methods and baseline data
Dysken, Maurice W.,
Guarino, Peter D.,
Vertrees, Julia E.,
Asthana, Sanjay,
Sano, Mary,
Llorente, Maria,
Pallaki, Muralidhar,
Love, Susan,
Schellenberg, Gerard D.,
McCarten, J. Riley,
Malphurs, Julie,
Prieto, Susana,
Chen, Peijun,
Loreck, David J.,
Carney, Sara,
Trapp, George,
Bakshi, Rajbir S.,
Mintzer, Jacobo E.,
Heidebrink, Judith L.,
Vidal-Cardona, Ana,
Arroyo, Lillian M.,
Cruz, Angel R.,
Kowall, Neil W.,
Chopra, Mohit P.,
Craft, Suzanne,
Thielke, Stephen,
Turvey, Carolyn L.,
Woodman, Catherine,
Monnell, Kimberly A.,
Gordon, Kimberly,
Tomaska, Julie,
Vatassery, Govind
Background: Alzheimer’s disease (AD) has been associated with both oxidative stress and excessive glutamate activity. A clinical trial was designed to compare the effectiveness of (i) alpha-tocopherol, a vitamin E antioxidant; (ii) memantine (Namenda), an N-methyl-D-aspartate antagonist; (iii) their combination; and (iv) placebo in delaying clinical progression in AD.; Methods: The Veterans Affairs Cooperative Studies […]
The GERAS study: A prospective observational study of costs and resource use in community dwellers with Alzheimer’s disease in three European countries—Study design and baseline findings
Wimo, Anders,
Reed, Catherine C.,
Dodel, Richard,
Belger, Mark,
Jones, Roy W.,
Happich, Michael,
Argimon, Josep M.,
Bruno, Giuseppe,
Novick, Diego,
Vellas, Bruno,
Haro, Josep Maria
To address socioeconomic challenges associated with its increasing prevalence, data are needed on country-level resource use and costs associated with Alzheimer’s disease (AD). GERAS is an 18-month observational study being conducted in France, Germany, and the UK (with an 18-month extension in France and Germany), aimed at determining resource use and total costs associated with […]
Response to cholinesterase inhibitors affects lifespan in Alzheimer’s disease
Background: A varying response to cholinesterase inhibitor (ChEI) treatment has been reported among patients with Alzheimer’s disease (AD). Whether the individual-specific response, specific ChEI agent or dose affects mortality is unclear. We aimed to examine the relationship between the 6-month response to ChEI and lifespan. Methods: Six hundred and eighty-one deceased patients with a clinical […]
A follow‐up intervention in severely demented patients after discharge from a special Alzheimer acute care unit: Impact on early emergency room re‐hospitalization rate
Villars, Hélène,
Dupuy, Charlotte,
Soler, Pauline,
Gardette, Virginie,
Soto, Maria E.,
Gillette, Sophie,
Nourhashemi, Fati,
Vellas, Bruno
Background: Emergency room (ER) re-hospitalizations are prevalent in severe Alzheimer’s disease affected older patients. Design: Quasi-experimental before and after study. Setting: Discharge of severely demented patients from a Special Alzheimer Acute Care Unit. Participants: A total of 390 patients hospitalized in the unit from 2007 through 2009, with at least one of the following characteristics: […]
Outcomes of interventions for Alzheimer’s family caregivers in Mexico
The study examines which of three interventions of cognitive conduct, laughter, or a mixed intervention including both cognitive conduct and laughter components, is more effective for improvement of attitudes toward care and reduction of anxiety among female Mexican caregivers of family members with Alzheimer’s disease. A repeated measures quasi-experimental design with four groups, three experimental […]
Physical activity attenuates age-related biomarker alterations in preclinical AD
Okonkwo, O. C.,
Schultz, S. A.,
Oh, J. M.,
Larson, J.,
Edwards, D.,
Cook, D.,
Koscik, R.,
Gallagher, C. L.,
Dowling, N. M.,
Carlsson, C. M.,
Bendlin, B. B.,
LaRue, A.,
Rowley, H. A.,
Christian, B. T.,
Asthana, S.,
Hermann, B. P.,
Johnson, S. C.,
Sager, M. A.
Objective: To examine whether engagement in physical activity might favorably alter the agedependent evolution of Alzheimer disease (AD)-related brain and cognitive changes in a cohort of at-risk, late-middle-aged adults. Methods: Three hundred seventeen enrollees in the Wisconsin Registry for Alzheimer’s Prevention underwent T1 MRI; a subset also underwent ¹¹C-Pittsburgh compound B–PET (n = 186) and […]