This database contains 524 studies, archived under the term: "alzheimer disease"
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Optimal blood pressure for cognitive function: findings from an elderly African-American cohort study
Liu, Hai,
Gao, Sujuan,
Hall, Kathleen S.,
Unverzagt, Frederick W.,
Lane, Kathleen A.,
Callahan, Christopher M.,
Hendrie, Hugh C.
Objectives: To report the results from a prospective cohort study on the association between blood pressure (BP) and cognitive function in elderly African Americans.; Design: Prospective cohort study conducted from 1997 to 2009.; Setting: Community-based study in Indianapolis.; Participants: African Americans aged 65 years or older (N = 3,145).; Measurements: At each assessment, participant cognitive […]
Deep learning based imaging data completion for improved brain disease diagnosis
Li, Rongjian,
Zhang, Wenlu,
Suk, Heung-Il,
Wang, Li,
Li, Jiang,
Shen, Dinggang,
Ji, Shuiwang
Combining multi-modality brain data for disease diagnosis commonly leads to improved performance. A challenge in using multimodality data is that the data are commonly incomplete; namely, some modality might be missing for some subjects. In this work, we proposed a deep learning based framework for estimating multi-modality imaging data. Our method takes the form of […]
The effect of an aloe polymannose multinutrient complex on cognitive and immune functioning in Alzheimer’s disease
Lewis, John E.,
McDaniel, H. Reginald,
Agronin, Marc E.,
Loewenstein, David A.,
Riveros, Jorge,
Mestre, Rafael,
Martinez, Mairelys,
Colina, Niurka,
Abreu, Dahlia,
Konefal, Janet,
Woolger, Judi M.,
Ali, Karriem H.
Alzheimer’s disease (AD) is a leading killer of Americans, imparts a significant toll on the quality of life of the patient and primary caregiver, and results in inordinate costs in an already overburdened medical system. Prior studies on cholinesterase inhibitors among AD patients have shown minimal amelioration of disease symptoms and/or restoration of lost cognitive […]
Comparison of two analytical platforms for the clinical qualification of Alzheimer’s disease biomarkers in pathologically-confirmed dementia
Le Bastard, Nathalie,
Coart, Els,
Vanderstichele, Hugo,
Vanmechelen, Eugeen,
Martin, Jean-Jacques,
Engelborghs, Sebastiaan
Combined analysis of the Alzheimer’s disease (AD) biomarkers amyloid-β(1-42) (Aβ(1-42)), total tau (T-tau), and hyperphosphorylated tau (P-tau(181P)) in cerebrospinal fluid (CSF) reduces the uncertainty associated with clinical dementia diagnosis. The present study evaluated the diagnostic accuracy of the CSF biomarker concentrations obtained with a multi-analyte Luminex assay (INNO-BIA AlzBio3) in comparison to single-analyte ELISA tests […]
Memantine is associated with longer survival than donepezil in a Veterans Affairs prescription database, 1997 to 2008
Lazzeroni, Laura C.,
Halbauer, Joshua D.,
Ashford, J. Wesson,
Noda, Art,
Hernandez, Beatriz,
Azor, Virgina,
Hozack, Nikki,
Hasson, Noelle,
Henderson, Victor W.,
Yesavage, Jerome A.,
Tinklenberg, Jared R.
Alzheimer’s disease (AD) shortens life-expectancy, but the effects of pharmacological treatments for this disorder on mortality have not been studied. We compared two commonly prescribed medications, donepezil and memantine, with respect to the length of survival of veterans presumed to have AD. The Computerized Medical Records System at the Veterans Affairs Palo Alto Health Care […]
Effect of methylphenidate on attention in apathetic AD patients in a randomized, placebo-controlled trial
Lanctôt, Krista L.,
Chau, Sarah A.,
Herrmann, Nathan,
Drye, Lea T.,
Rosenberg, Paul B.,
Scherer, Roberta W.,
Black, Sandra E.,
Vaidya, Vijay,
Bachman, David L.,
Mintzer, Jacobo E.
Background: Little is known about the effect of methylphenidate (MPH) on attention in Alzheimer’s disease (AD). MPH has shown to improve apathy in AD, and both apathy and attention have been related to dopaminergic function. The goal was to investigate MPH effects on attention in AD and assess the relationship between attention and apathy responses.; […]
Self-regulated music stimulation for persons with Alzheimer’s disease: impact assessment and social validation
Lancioni, Giulio E.,
Singh, Nirbhay N.,
O’Reilly, Mark F.,
Green, Vanessa A.,
Ferlisi, Gabriele,
Ferrarese, Giacomina,
Zullo, Valeria,
Perilli, Viviana,
Cassano, Germana,
Cordiano, Noemi,
Pinto, Katia,
Zonno, Nadia
Objective: To assess the impact and the social rating of an active music condition (in which 10 patients with Alzheimer’s disease regulated their music input) vs. a passive music condition.; Method: In the active condition, the patients used a simple hand response and a microswitch to activate music stimulation periods. In the passive condition, music […]
Technology-based orientation programs to support indoor travel by persons with moderate Alzheimer’s disease: impact assessment and social validation
Lancioni, Giulio E.,
Perilli, Viviana,
O’Reilly, Mark F.,
Singh, Nirbhay N.,
Sigafoos, Jeff,
Bosco, Andrea,
Caffò, Alessandro O.,
Picucci, Luciana,
Cassano, Germana,
Groeneweg, Jop
The present study (a) extended the assessment of an orientation program involving auditory cues (i.e., verbal messages automatically presented from the destinations) with five patients with Alzheimer’s disease, (b) compared the effects of this program with those of a program with light cues (i.e., a program in which strobe lights were used instead of the […]
Assessing the impact and social perception of self-regulated music stimulation with patients with Alzheimer’s disease
Lancioni, Giulio E.,
O’Reilly, Mark F.,
Singh, Nirbhay N.,
Sigafoos, Jeff,
Grumo, Gianluca,
Pinto, Katia,
Stasolla, Fabrizio,
Signorino, Mario,
Groeneweg, Jop
We assessed the impact and social rating of an active and a passive music condition implemented with six patients with Alzheimer’s disease. In the active condition, the patients used a simple hand response and a microswitch to self-regulate music stimulation inputs. In the passive condition, music stimulation was automatically presented throughout the sessions. Active and […]