This database contains 524 studies, archived under the term: "alzheimer disease"
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The UP-TECH project, an intervention to support caregivers of Alzheimer’s disease patients in Italy: study protocol for a randomized controlled trial
Chiatti, Carlos,
Masera, Filippo,
Rimland, Joseph M.,
Cherubini, Antonio,
Scarpino, Osvaldo,
Spazzafumo, Liana,
Lattanzio, Fabrizia
Background: The epidemic of Alzheimer’s disease (AD) represents a significant challenge for the health care and social service systems of many developed countries. AD affects both patients and family caregivers, on whom the main burden of care falls, putting them at higher risk of stress, anxiety, mortality and lower quality of life. Evidence remains controversial […]
German adaptation of the Resources for Enhancing Alzheimer’s Caregiver Health II: study protocol of a single-centred, randomised controlled trial
Heinrich, Stephanie,
Berwig, Martin,
Simon, Anke,
Jänichen, Jenny,
Hallensleben, Nina,
Nickel, Witiko,
Hinz, Andreas,
Brähler, Elmar,
Gertz, Hermann-Josef
Background: Caring for a family member with dementia is extremely stressful, and contributes to psychiatric and physical illness among caregivers. Therefore, a comprehensive programme called Resources for Enhancing Alzheimer’s Caregiver Health II (REACH II) was developed in the United States to enhance the health of Alzheimer’s caregivers. REACH II causes a clear reduction of the […]
Alzheimer’s disease–input of vitamin D with mEmantine assay (AD-IDEA trial): study protocol for a randomized controlled trial
Annweiler, Cedric,
Fantino, Bruno,
Parot-Schinkel, Elsa,
Thiery, Samuel,
Gautier, Jennifer,
Beauchet, Olivier
Background: Current treatments for Alzheimer’s disease and related disorders (ADRD) are symptomatic and can only temporarily slow down ADRD. Future possibilities of care rely on multi-target drugs therapies that address simultaneously several pathophysiological processes leading to neurodegeneration. We hypothesized that the combination of memantine with vitamin D could be neuroprotective in ADRD, thereby limiting neuronal […]
Early detection of patients in the pre demented stage of Alzheimer’s disease: the Pre-Al Study
Mahieux, F.,
Onen, F.,
Berr, C.,
Volteau, M.,
Habert, M. O.,
Legrain, S.,
Dubois, B.
Objectives: The aim of the Pre-Al study is to evaluate and compare the predictive value of different tools for an early identification of Alzheimer’s disease.; Design and Participants: Patients coming for consultation to memory clinics without dementia were included if they had an objective memory or attention trouble assessed by a MMSE score > 25 […]
Exercise rehabilitation on home-dwelling patients with Alzheimer’s disease–a randomized, controlled trial. Study protocol
Pitkälä, Kaisu H.,
Raivio, Minna M.,
Laakkonen, Marja-Liisa,
Tilvis, Reijo S.,
Kautiainen, Hannu,
Strandberg, Timo E.
Background: Besides cognitive decline, Alzheimer’s disease (AD) leads to physical disability, need for help and permanent institutional care. The trials investigating effects of exercise rehabilitation on physical functioning of home-dwelling older dementia patients are still scarce. The aim of this study is to investigate the effectiveness of intensive exercise rehabilitation lasting for one year on […]
Preserving cognition, quality of life, physical health and functional ability in Alzheimer’s disease: the effect of physical exercise (ADEX trial): rationale and design
Hoffmann, Kristine,
Frederiksen, Kristian S.,
Sobol, Nanna Aue,
Beyer, Nina,
Vogel, Asmus,
Simonsen, Anja Hviid,
Johannsen, Peter,
Lolk, Annette,
Terkelsen, Ole,
Cotman, Carl W.,
Hasselbalch, Steen G.,
Waldemar, Gunhild
Background: Exercise is hypothesized to improve cognition, physical performance, functional ability and quality of life, but evidence is scarce. Previous studies were of short duration, often underpowered and involving home-based light exercise programs in patients with undefined dementia. The aim of the ADEX (‘Preserving Cognition, Quality of Life, Physical Health and Functional Ability in Alzheimer’s […]
The Danish Alzheimer intervention study: rationale, study design and baseline characteristics of the cohort
WALDEMAR, G.,
Waldorff, F. B.,
Buss, D. V.,
Eckermann, A.,
Keiding, N.,
Rishøj, S.,
Siersma, V.,
Sørensen, J.,
Sørensen, L. V.,
VOGEL, A.
Background: There is a lack of appropriately designed trials investigating the efficacy of psychosocial interventions for patients with mild dementia and their family caregivers. This paper reports the rationale and design of the Danish Alzheimer Disease Intervention Study and baseline characteristics of the cohort.; Methods: The study was a 1-year multicentre randomized controlled rater-blinded trial […]
Study of Mental Activity and Regular Training (SMART) in at risk individuals: a randomised double blind, sham controlled, longitudinal trial
Gates, Nicola J.,
Valenzuela, Michael,
Sachdev, Perminder S.,
Singh, Nalin A.,
Baune, Bernhard T.,
Brodaty, Henry,
Suo, Chao,
Jain, Nidhi,
Wilson, Guy C.,
Wang, Yi,
Baker, Michael K.,
Williamson, Dominique,
Foroughi, Nasim,
Fiatarone Singh, Maria A.
Background: The extent to which mental and physical exercise may slow cognitive decline in adults with early signs of cognitive impairment is unknown. This article provides the rationale and methodology of the first trial to investigate the isolated and combined effects of cognitive training (CT) and progressive resistance training (PRT) on general cognitive function and […]
Comparing registration methods for mapping brain change using tensor-based morphometry
Measures of brain changes can be computed from sequential MRI scans, providing valuable information on disease progression for neuroscientific studies and clinical trials. Tensor-based morphometry (TBM) creates maps of these brain changes, visualizing the 3D profile and rates of tissue growth or atrophy. In this paper, we examine the power of different nonrigid registration models […]