This site uses cookies to measure how you use the website so it can be updated and improved based on your needs and also uses cookies to help remember the notifications you’ve seen, like this one, so that we don’t show them to you again. If you could also tell us a little bit about yourself, this information will help us understand how we can support you better and make this site even easier for you to use and navigate.

The Danish Alzheimer intervention study: rationale, study design and baseline characteristics of the cohort


WALDEMAR, G., Waldorff, F. B., Buss, D. V., Eckermann, A., Keiding, N., Rishøj, S., Siersma, V., Sørensen, J., Sørensen, L. V., VOGEL, A.


Neuroepidemiology, Volume: 36, No.: 1, Pages.: 52-61

Year of Publication



Background: There is a lack of appropriately designed trials investigating the efficacy of psychosocial interventions for patients with mild dementia and their family caregivers. This paper reports the rationale and design of the Danish Alzheimer Disease Intervention Study and baseline characteristics of the cohort.; Methods: The study was a 1-year multicentre randomized controlled rater-blinded trial with randomization to follow-up and a multifaceted semitailored intervention programme or to follow-up only (with extension of follow-up to 3 years). The intervention included a counselling programme, teaching courses, written information and logbooks. The outcomes included clinical efficacy parameters, patient satisfaction and health economic consequences.; Results: A total of 330 patients and their 330 caregivers were included during a period of 18 months. The majority (65.2 %) of the caregivers were spouses. At inclusion the mean age of the patients and caregivers was 76.2 and 66.0 years, respectively.; Conclusion: The study will explore the added value of a multifaceted intervention programme and contribute to the design of future interventions for patients with mild dementia and their caregivers.; Copyright © 2010 S. Karger AG, Basel.

Bibtex Citation

@article{Waldemar_2011, doi = {10.1159/000322942}, url = {}, year = 2011, publisher = {S. Karger {AG}}, volume = {36}, number = {1}, pages = {52--61}, author = {G. Waldemar and F.B. Waldorff and D.V. Buss and A. Eckermann and N. Keiding and S. Rish{o}j and V. Siersma and J. S{o}rensen and L.V. S{o}rensen and A. Vogel}, title = {The Danish Alzheimer Intervention Study: Rationale, Study Design and Baseline Characteristics of the Cohort}, journal = {Neuroepidemiology} }


aged, aged, 80 and over, alzheimer disease, caregivers, clinical protocols, counseling, female, humans, male, middle aged, patient satisfaction, prospective studies, psychology, psychosocial, therapy

Countries of Study


Types of Dementia

Alzheimer’s Disease

Types of Study

Cost and service use study, Randomised Controlled Trial

Type of Outcomes

Satisfaction with care/services, Service use or cost reductions (incl. hospital use reduction, care home admission delay)

Type of Interventions

Intervention for Carers, Non-pharmacological Treatment

Non-Pharmaceutical Interventions

Behavioural Therapies

Carer Focussed Interventions