This database contains 750 studies, archived under the term: "aged, 80 and over"
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Longitudinal changes in white matter disease and cognition in the first year of the Alzheimer disease neuroimaging initiative
Carmichael, Owen,
Schwarz, Christopher,
Drucker, David,
Fletcher, Evan,
Harvey, Danielle,
Beckett, Laurel,
Jack, Clifford R., Jr.,
Weiner, Michael,
DeCarli, Charles
Objective: To evaluate relationships between magnetic resonance imaging (MRI)-based measures of white matter hyperintensities (WMHs), measured at baseline and longitudinally, and 1-year cognitive decline using a large convenience sample in a clinical trial design with a relatively mild profile of cardiovascular risk factors.; Design: Convenience sample in a clinical trial design.; Subjects: A total of […]
Transcultural influences in dementia care: observations from a psychosocial intervention study
Burns, Alistair,
Mittelman, Mary,
Cole, Catherine,
Morris, Julie,
Winter, Jane,
Page, Sean,
Brodaty, Henry
Background: Various models of intervention for caregivers of patients with dementia have been described. There has been little direct comparison of cultural differences between countries and the effect any differences may exert on the outcome of caregiver interventions.; Aims: The aims of the three-country study (USA, Australia and the UK) were to assess whether caregiver […]
Reduction of aggregated Tau in neuronal processes but not in the cell bodies after Abeta42 immunisation in Alzheimer’s disease
Boche, Delphine,
Donald, Jane,
Love, Seth,
Harris, Scott,
Neal, James W.,
Holmes, Clive,
Nicoll, James A. R.
Alzheimer’s disease (AD) pathology is characterised by aggregation in the brain of amyloid-beta (Abeta) peptide and hyperphosphorylated tau (phospho-tau), although how these proteins interact in disease pathogenesis is unclear. Abeta immunisation results in removal of Abeta from the brain but cognitive decline continues to progress, possibly due to persistent phospho-tau. We quantified phospho-tau and Abeta42 […]
A single ascending dose study of bapineuzumab in patients with Alzheimer disease
Black, Ronald S.,
Sperling, Reisa A.,
Safirstein, Beth,
Motter, Ruth N.,
Pallay, Allan,
Nichols, Alice,
Grundman, Michael
The safety, tolerability, and pharmacokinetics (PKs) of bapineuzumab (AAB-001), a humanized monoclonal antibody to amyloid beta, were evaluated in patients with mild-to-moderate Alzheimer disease in a phase 1, randomized, third-party unblinded, placebo-controlled, single ascending dose trial. Thirty patients received bapineuzumab infusion of 0.5, 1.5, or 5 mg/kg or placebo (6 active, 2 placebo for 0.5 […]
Validity of the free and cued selective reminding test in predicting dementia: the 3C study
Auriacombe, S.,
Helmer, C.,
Amieva, H.,
Berr, C.,
Dubois, B.,
Dartigues, J. F.
Objective: We assessed the validity of the Free and Cued Selective Reminding Test (FCSRT) in predicting dementia 2 and 5 years after initial evaluation in a population-based cohort over age 65 years participating in the French 3 Cities (3C) study.; Methods: The FCSRT was administered at baseline along with demographics, cognitive and functional scales, and […]
Rosiglitazone and cognitive stability in older individuals with type 2 diabetes and mild cognitive impairment
Abbatecola, Angela M.,
Lattanzio, Fabrizia,
Molinari, Anna M.,
Cioffi, Michele,
Mansi, Luigi,
Rambaldi, Pierfrancesco,
DiCioccio, Luigi,
Cacciapuoti, Federico,
Canonico, Raffaele,
Paolisso, Giuseppe
Objective: Studies have suggested that insulin resistance plays a role in cognitive impairment in individuals with type 2 diabetes. We aimed to determine whether an improvement in insulin resistance could explain cognitive performance variations over 36 weeks in older individuals with mild cognitive impairment (MCI) and type 2 diabetes.; Research Design and Methods: A total […]
Effectiveness of donepezil in reducing clinical worsening in patients with mild-to-moderate alzheimer’s disease
Wilkinson, David,
Schindler, Rachel,
Schwam, Elias,
Waldemar, Gunhild,
Jones, Roy W.,
Gauthier, Serge,
Lopez, Oscar L.,
Cummings, Jeffrey,
Xu, Yikang,
Feldman, Howard H.
Background: Therapeutic endpoints based on reduced clinical worsening represent clinically relevant and realistic goals for patients suffering from progressive neurodegenerative disorders such as Alzheimer’s disease (AD).; Methods: Data from 906 patients (388 receiving placebo; 518 receiving donepezil) with mild-to-moderate AD [Mini-Mental State Examination (MMSE) score 10-27] were pooled from 3 randomized, double-blind placebo-controlled studies. Clinical […]
A practice-based intervention to improve primary care for falls, urinary incontinence, and dementia
Wenger, Neil S.,
Roth, Carol P.,
Shekelle, Paul G.,
Young, Roy T.,
Solomon, David H.,
Kamberg, Caren J.,
Chang, John T.,
Louie, Rachel,
Higashi, Takahiro,
MacLean, Catherine H.,
Adams, John,
Min, Lillian C.,
Ransohoff, Kurt,
Hoffing, Marc,
Reuben, David B.
Objectives: To determine whether a practice-based intervention can improve care for falls, urinary incontinence, and cognitive impairment.; Design: Controlled trial.; Setting: Two community medical groups.; Participants: Community-dwelling patients (357 at intervention sites and 287 at control sites) aged 75 and older identified as having difficulty with falls, incontinence, or cognitive impairment.; Intervention: Intervention and control […]