Louis, Elan D., Benito-León, Julián, Bermejo-Pareja, Félix

Background: Recent interest in antihypertensive agents, especially calcium channel blockers, has been sparked by the notion that these medications may be neuroprotective. A modest literature, with mixed results, has examined whether these medications might lower the odds or risk of Parkinson’s disease (PD) or dementia. There are no data for essential tremor (ET).; Objective: To […]

Hoffmann, Kristine, Frederiksen, Kristian S., Sobol, Nanna Aue, Beyer, Nina, Vogel, Asmus, Simonsen, Anja Hviid, Johannsen, Peter, Lolk, Annette, Terkelsen, Ole, Cotman, Carl W., Hasselbalch, Steen G., Waldemar, Gunhild

Background: Exercise is hypothesized to improve cognition, physical performance, functional ability and quality of life, but evidence is scarce. Previous studies were of short duration, often underpowered and involving home-based light exercise programs in patients with undefined dementia. The aim of the ADEX (‘Preserving Cognition, Quality of Life, Physical Health and Functional Ability in Alzheimer’s […]

WALDEMAR, G., Waldorff, F. B., Buss, D. V., Eckermann, A., Keiding, N., Rishøj, S., Siersma, V., Sørensen, J., Sørensen, L. V., VOGEL, A.

Background: There is a lack of appropriately designed trials investigating the efficacy of psychosocial interventions for patients with mild dementia and their family caregivers. This paper reports the rationale and design of the Danish Alzheimer Disease Intervention Study and baseline characteristics of the cohort.; Methods: The study was a 1-year multicentre randomized controlled rater-blinded trial […]

Shah, Raj C., Wilson, Robert S., Tang, Yuxiao, Dong, Xinqi, Murray, Anne, Bennett, David A.

Background: While decreased hemoglobin concentration is common in the elderly, the relationship of the entire range of hemoglobin concentrations with cognitive function is not well understood.; Methods: Cross-sectional analyses were conducted utilizing data from community-dwelling, older persons participating in the Rush Memory and Aging Project. Proximate to first available hemoglobin measurement, 21 cognitive tests were […]