Cyarto, Elizabeth V., Lautenschlager, Nicola T., Desmond, Patricia M., Ames, David, Szoeke, Cassandra, Salvado, Olivier, Sharman, Matthew J., Ellis, Kathryn A., Phal, Pramit M., Masters, Colin L., Rowe, Christopher C., Martins, Ralph N., Cox, Kay L.

Background: Older adults free of dementia but with subjective memory complaints (SMC) or mild cognitive impairment (MCI) are considered at increased risk of cognitive decline. Vascular risk factors (VRF), including hypertension, heart disease, smoking, hypercholesterolemia and lack of physical activity (PA) have been identified as modifiable risk factors contributing to cognitive decline, and white matter […]

Gerritsen, Debby L, Smalbrugge, Martin, Teerenstra, Steven, Leontjevas, Ruslan, Adang, Eddy M., Vernooij-Dassen, Myrra J. F. J., Derksen, Els, Koopmans, Raymond T. C. M.

Background: The aim of this study is evaluating the (cost-) effectiveness of a multidisciplinary, evidence based care program to improve the management of depression in nursing home residents of somatic and dementia special care units. The care program is an evidence based standardization of the management of depression, including standardized use of measurement instruments and […]

Smeets, Claudia H. W., Smalbrugge, Martin, Gerritsen, Debby L, Nelissen-Vrancken, Marjorie H. J. M. G., Wetzels, Roland B., van der Spek, Klaas, Zuidema, Sytse U., Koopmans, Raymond T. C. M.

Background: Neuropsychiatric symptoms are highly prevalent in nursing home patients with dementia. Despite modest effectiveness and considerable side effects, psychotropic drugs are frequently prescribed for these neuropsychiatric symptoms. This raises questions whether psychotropic drugs are appropriately prescribed. The aim of the PROPER (PRescription Optimization of Psychotropic drugs in Elderly nuRsing home patients with dementia) II […]

Blom, Marco M., Bosmans, Judith E, Cuijpers, Pim, Zarit, Steve H., Pot, Anne-Margriet

Background: The number of people with dementia is rising rapidly as a consequence of the greying of the world population. There is an urgent need to develop cost effective approaches that meet the needs of people with dementia and their family caregivers. Depression, feelings of burden and caregiver stress are common and serious health problems […]

Dannhauser, Thomas M., Cleverley, Martin, Whitfield, Tim J., Fletcher, Ben, Stevens, Tim, Walker, Zuzana

Background: Dementia affects 35 million people worldwide and is currently incurable. Many cases may be preventable because regular participation in physical, mental and social leisure activities during middle age is associated with up to 47% dementia risk reduction. However, the majority of middle-aged adults are not active enough. MCI is therefore a clear target for […]