This database contains 477 studies, archived under the term: "Non-pharmacological Treatment"
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Cognitive, emotional, and social benefits of regular musical activities in early dementia: randomized controlled study
Sarkamo, T.,
Tervaniemi, M.,
Laitinen, S.,
Numminen, A.,
Kurki, M.,
Johnson, J. K.,
Rantanen, P.
PURPOSE OF THE STUDY: During aging, musical activities can help maintain physical and mental health and cognitive abilities, but their rehabilitative use has not been systematically explored in persons with dementia (PWDs). Our aim was to determine the efficacy of a novel music intervention based on coaching the caregivers of PWDs to use either singing […]
A new combined strategy to implement a community occupational therapy intervention: designing a cluster randomized controlled trial
Döpp, Carola M. E.,
Graff, Maud J. L.,
Teerenstra, Steven,
Adang, Eddy,
Nijhuis-van der Sanden, Ria W. G.,
Olderikkert, Marcel G. M.,
Vernooij-Dassen, Myrra J. F. J.
Background: Even effective interventions for people with dementia and their caregivers require specific implementation efforts. A pilot study showed that the highly effective community occupational therapy in dementia (COTiD) program was not implemented optimally due to various barriers. To decrease these barriers and make implementation of the program more effective a combined implementation (CI) strategy […]
Diet intervention and cerebrospinal fluid biomarkers in amnestic mild cognitive impairment
Bayer-Carter, Jennifer L.,
Green, Pattie S.,
Montine, Thomas J.,
VanFossen, Brian,
Baker, Laura D.,
Watson, G. Stennis,
Bonner, Laura M.,
Callaghan, Maureen,
Leverenz, James B.,
Walter, Brooke K.,
Tsai, Elaine,
Plymate, Stephen R.,
Postupna, Nadia,
Wilkinson, Charles W.,
Zhang, Jing,
Lampe, Johanna,
Kahn, Steven E.,
Craft, Suzanne
Objective: To compare the effects of a 4-week high-saturated fat/high-glycemic index (HIGH) diet with a low-saturated fat/low-glycemic index (LOW) diet on insulin and lipid metabolism, cerebrospinal fluid (CSF) markers of Alzheimer disease, and cognition for healthy adults and adults with amnestic mild cognitive impairment (aMCI).; Design: Randomized controlled trial.; Setting: Veterans Affairs Medical Center clinical […]
Improved language performance in Alzheimer disease following brain stimulation
Cotelli, Maria,
Calabria, Marco,
Manenti, Rosa,
Rosini, Sandra,
Zanetti, Orazio,
Cappa, Stefano F.,
Miniussi, Carlo
Objectives: Repetitive transcranial magnetic stimulation (rTMS) has been proposed as a possible treatment for the cognitive deficits associated with Alzheimer disease (AD). The aim of this study was to assess the long-term effects, on cognitive performance, of rTMS applied to the left dorsolateral prefrontal cortex (DLPFC) in AD patients.; Methods: Ten AD patients were randomly […]
Effectiveness of nonpharmacological approaches in patients with mild cognitive impairment
Tsolaki, Magda,
Kounti, Fotini,
Agogiatou, Christina,
Poptsi, Eleni,
Bakoglidou, Evangelia,
Zafeiropoulou, Myrto,
Soumbourou, Aikaterini,
Nikolaidou, Evdokia,
Batsila, Georgia,
Siambani, Aikaterini,
Nakou, Stella,
Mouzakidis, Christos,
Tsiakiri, Anna,
Zafeiropoulos, Stavros,
Karagiozi, Konstantina,
Messini, Chaido,
Diamantidou, Alexandra,
Vasiloglou, Maria
Background: Mild cognitive impairment (MCI) patients are at increased risk of developing dementia. There is a conflict if cognitive interventions can improve cognitive and functional performances in order to delay the development of dementia.; Objectives: This study aimed to examine the effectiveness of a holistic cognitive rehabilitation program on patients with MCI.; Methods: The participants, […]
Systematic care for caregivers of patients with dementia: a multicenter, cluster-randomized, controlled trial
Spijker, Anouk,
Wollersheim, Hub,
Teerenstra, Steven,
Graff, Maud,
Adang, Eddy,
Verhey, Frans,
Vernooij-Dassen, Myrra
Objective: To evaluate the effectiveness of the Systematic Care Program for Dementia (SCPD) on patient institutionalization and to determine the predictors of institutionalization.; Design: Single-blind, multicenter, cluster-randomized, controlled trial.; Setting: Six community mental health services (CMHSs) across the Netherlands.; Participants: A total of 295 patient-caregiver dyads referred to a CMHS with suspected patient dementia.; Intervention: […]
The effects of behavioral activation therapy with inpatient geriatric psychiatry patients
Snarski, Melissa,
Scogin, Forrest,
DiNapoli, Elizabeth,
Presnell, Andrew,
McAlpine, Jessie,
Marcinak, Jacquelyn
This study examined the effects of Behavioral Activation (BA) treatment on depressive symptoms and quality of life among older adult patients in a geriatric psychiatry facility. There were 50 participants with mild to moderate cognitive impairment, each being 65 years of age or older. A 2 (between)×3 (time of measurement) design was used in this […]
Health and nutrition promotion program for patients with dementia (NutriAlz): cluster randomized trial
Salva, A.,
Andrieu, S.,
Fernandez, E.,
Schiffrin, E. J.,
Moulin, J.,
Decarli, B.,
Rojano-i-Luque, X.,
Guigoz, Y.,
Vellas, B.
Objective: To assess the effectiveness of health and nutrition program (NutriAlz) versus usual care on functional level in elderly people with dementia living at home, as well as on clinical practice related to nutrition and on the caregiver’s burden.; Design: Cluster randomized multi-centre study with one-year follow-up.; Setting: 11 Alzheimer outpatients and day care centres […]