This database contains 22 studies, archived under the term: "Norway"
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Impact of a stepwise protocol for treating pain on pain intensity in nursing home patients with dementia: A cluster randomized trial
Sandvik, R. K.,
Selbaek, G.,
Seifert, R.,
Aarsland, D.,
Ballard, C.,
Corbett, A.,
Husebo, B. S.
Background: Pain is frequent and distressing in people with dementia, but no randomized controlled trials have evaluated the effect of analgesic treatment on pain intensity as a key outcome. Methods: Three hundred fifty‐two people with dementia and significant agitation from 60 nursing home units were included in this study. These units, representing 18 nursing homes […]
Plasma free choline, betaine and cognitive performance: the Hordaland Health Study
Nurk, Eha,
Refsum, Helga,
Bjelland, Ingvar,
Drevon, Christian A.,
Tell, Grethe S.,
Ueland, Per M.,
Vollset, Stein E.,
Engedal, Knut,
Nygaard, Harald A.,
Smith, David A.
Choline and betaine are nutrients involved in one-carbon metabolism. Choline is essential for neurodevelopment and brain function. We studied the associations between cognitive function and plasma concentrations of free choline and betaine. In a cross-sectional study, 2195 subjects (55 % women), aged 70-74 years, underwent extensive cognitive testing including the Kendrick Object Learning Test (KOLT), […]
The effect of person-centred dementia care to prevent agitation and other neuropsychiatric symptoms and enhance quality of life in nursing home patients: A 10-month randomized controlled trial
Rokstad, Anne Marie Mork,
Røsvik, Janne,
Kirkevold, Øyvind,
Selbaek, Geir,
Saltyte Benth, Jurate,
Engedal, Knut
Aims: We examined whether Dementia Care Mapping (DCM) or the VIPS practice model (VPM [Valuing people with dementia and those who care for them (V); treating people as Individuals (I); looking at the world from the Perspective of the person with dementia (P); and a positive Social environment in which the person living with dementia […]
Cognitive effects of reducing anticholinergic drug burden in a frail elderly population: a randomized controlled trial
Kersten, H.,
Molden, E.,
Tolo, I. K.,
Skovlund, E.,
Engedal, K.,
Wyller, T. B.
Background: Observational studies report a relationship between anticholinergic drug scale (ADS) score and cognitive function. This study investigated whether a reduced ADS score improved cognitive function in a frail elderly population.; Methods: This randomized, controlled, single-blinded trial, recruited long-term residents with an ADS score of greater than or equal to 3 from 22 nursing homes […]
Efficacy of memantine in PDD and DLB: an extension study including washout and open-label treatment
Johansson, C.,
Ballard, C.,
Hansson, O.,
Palmqvist, S.,
Minthon, L.,
Aarsland, D.,
Londos, E.
Objective: This 30-week extension trial was a continuation of the first double-blind randomized controlled trial (RCT) to study memantine in dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD). The objective was to evaluate the presence of recurrence of symptoms upon drug withdrawal. Furthermore, the aim was to explore washout dynamics in order to […]
Effects of cognitive training on gray matter volumes in memory clinic patients with subjective memory impairment
Engvig, Andreas,
Fjell, Anders M.,
Westlye, Lars T.,
Skaane, Nina V.,
Dale, Anders M.,
Holland, Dominic,
Due-Tønnessen, Paulina,
Sundseth, Øyvind,
Walhovd, Kristine B.
Subjective memory impairment (SMI) is a common risk factor for Alzheimer’s disease, with few established options for treatment. Here we investigate the effects of two months episodic memory training on regional brain atrophy in 19 memory clinic patients with SMI. We used a sensitive longitudinal magnetic resonance imaging protocol and compared the patients with 42 […]