Emre, Murat, Tsolaki, Magda, Bonuccelli, Ubaldo, Destée, Alain, Tolosa, Eduardo, Kutzelnigg, Alexandra, Ceballos-Baumann, Andrés, Zdravkovic, Slobodan, Bladström, Anna, Jones, Roy

Background: Previous studies have suggested that patients with Lewy-body-related dementias might benefit from treatment with the N-methyl D-aspartate receptor antagonist memantine, but further data are needed. Therefore, the efficacy and safety of memantine were investigated in patients with mild to moderate Parkinson’s disease dementia (PDD) or dementia with Lewy bodies (DLB).; Methods: Patients (≥50 years […]

Tsolaki, Magda, Kounti, Fotini, Agogiatou, Christina, Poptsi, Eleni, Bakoglidou, Evangelia, Zafeiropoulou, Myrto, Soumbourou, Aikaterini, Nikolaidou, Evdokia, Batsila, Georgia, Siambani, Aikaterini, Nakou, Stella, Mouzakidis, Christos, Tsiakiri, Anna, Zafeiropoulos, Stavros, Karagiozi, Konstantina, Messini, Chaido, Diamantidou, Alexandra, Vasiloglou, Maria

Background: Mild cognitive impairment (MCI) patients are at increased risk of developing dementia. There is a conflict if cognitive interventions can improve cognitive and functional performances in order to delay the development of dementia.; Objectives: This study aimed to examine the effectiveness of a holistic cognitive rehabilitation program on patients with MCI.; Methods: The participants, […]

Förstl, H., Stamouli, S. S., Janetzky, W., Galanopoulos, A., Karageorgiou, C., Tzanakaki, M.

Background/aims: Results from German and Greek non-interventional studies were compared to investigate possible differences concerning efficacy, tolerability and compliance between both countries.; Methods: In two open-label, multicentre, non-interventional studies, 4,305 patients with mild to severe Alzheimer’s disease (AD) were treated with daily doses of 20 mg memantine for 6 months. Efficacy was assessed using the […]

Paraskevas, G. P., Kapaki, E., Papageorgiou, S. G., Kalfakis, N., Andreadou, E., Zalonis, I., Vassilopoulos, D.

Background and Purpose: The differential diagnosis between vascular dementia (VD) and Alzheimer’s disease (AD) or mixed dementia (MD) is not always easy in clinical practice. The purpose of the present study was to evaluate the cerebrospinal fluid (CSF) biomarkers tau protein in its total (tau(T)) or hyperphosphorylated at threonin-181(tau(P-181)) form and beta amyloid peptide 1-42 […]

Kountouras, Jannis, Boziki, Marina, Gavalas, Emmanuel, Zavos, Christos, Grigoriadis, Nikolaos, Deretzi, Georgia, Tzilves, Dimitrios, Katsinelos, Panagiotis, Tsolaki, Magda, Chatzopoulos, Dimitrios, Venizelos, Ioannis

Infectious agents have been proposed as potential causes of Alzheimer’s disease (AD). Recently, we documented a high prevalence of Helicobacter pylori (Hp) infection in patients with AD. We aim to access the effect of Hp eradication on the AD cognitive (MMSE: Mini Mental State Examination and CAMCOG: Cambridge Cognitive Examination for the Elderly) and functional […]

Tsantali, Eleni, Economidis, Dimitris

The implications of a longitudinal (5 years) intervention program in a mild Alzheimer’s disease (mAD) patient targeting mainly the language deficits were investigated. The program had 2 parts: the intensive one included training strategies and tasks that enhanced his impairments (memory, naming, comprehension), and the second one (the next 4 years), without guidelines or teaching. […]

Torkamani, Mariam, McDonald, Louise, Saez Aguayo, Ignasi, Kanios, Christos, Katsanou, Maria-Nefeli, Madeley, Laura, Limousin, Patricia D., Lees, Andrew J., Haritou, Maria, Jahanshahi, Marjan

The use of telemedicine is becoming increasingly popular in assisting with the home management of People with Dementia (PwD) by offering services to the carers that may enhance their ability to care for their relative for longer. A computerized platform, ALADDIN, was evaluated in its usefulness to reduce carer burden and distress and to improve […]

Stoeck, K., Sanchez-Juan, P., Gawinecka, J., Green, A., Ladogana, A., Pocchiari, M., Sanchez-Valle, R., Mitrova, E., Sklaviadis, T., Kulczycki, J., Slivarichova, D., Saiz, A., Calero, M., Knight, R., Aguzzi, A., Laplanche, J.-L., Peoc'h, K., Schelzke, G., Karch, A., van Duijn, C. M., Zerr, I.

To date, cerebrospinal fluid analysis, particularly protein 14-3-3 testing, presents an important approach in the identification of Creutzfeldt-Jakob disease cases. However, one special point of criticism of 14-3-3 testing is the specificity in the differential diagnosis of rapid dementia. The constant observation of increased cerebrospinal fluid referrals in the national surveillance centres over the last […]