Wyller, Torgeir Bruun, Watne, Leiv Otto, Torbergsen, Anne, Engedal, Knut, Frihagen, Frede, Juliebø, Vibeke, Saltvedt, Ingvild, Skovlund, Eva, Ræder, Johan, Conroy, Simon

Background: Hip fractures mainly affect older people. It is associated with high morbidity and mortality, and in particular a high frequency of delirium. Incident delirium following hip fracture is associated with an increased risk of dementia in the following months, but it is still not firmly established whether this is an association or a causal […]

Andersen, Fred, Viitanen, Matti, Halvorsen, Dag S., Straume, Bjørn, Wilsgaard, Tom, Engstad, Torgeir A.

Background: Progressive neurodegeneration in Alzheimer’s disease (AD) induces cognitive deterioration, and there is controversy regarding the optimal treatment strategy in early AD. Stimulation therapy, including physical exercise and cholinesterase inhibitors are both reported to postpone cognitive deterioration in separate studies. We aimed to study the effect of stimulation therapy and the additional effect of donepezil […]

Sommer, Oskar H., Engedal, Knut

Objective: To examine the test-retest reliability and validity of the Norwegian Brief Agitation Rating Scale (BARS), a short form of the Cohen-Mansfield Agitation Inventory (CMAI) assessing the frequency of agitation in dementia.; Methods: We investigated the internal consistency, test-retest reliability and the validity of BARS. In the validity study, we compared the BARS scores with […]

Nurk, Eha, Refsum, Helga, Bjelland, Ingvar, Drevon, Christian A., Tell, Grethe S., Ueland, Per M., Vollset, Stein E., Engedal, Knut, Nygaard, Harald A., Smith, David A.

Choline and betaine are nutrients involved in one-carbon metabolism. Choline is essential for neurodevelopment and brain function. We studied the associations between cognitive function and plasma concentrations of free choline and betaine. In a cross-sectional study, 2195 subjects (55 % women), aged 70-74 years, underwent extensive cognitive testing including the Kendrick Object Learning Test (KOLT), […]

Kersten, Hege, Wyller, Torgeir B., Molden, Espen

Background: To compare measures of anticholinergic activity between metabolic phenotypes of the polymorphic enzymes cytochrome P450 2D6 (CYP2D6) and CYP2C19 in the elderly patients exposed to anticholinergic agents.; Methods: Long-term nursing home patients (n = 80) with an anticholinergic drug scale (ADS) score ≥3 were recruited from 22 nursing homes in Norway. Based on pharmacogenetic […]

Johansson, C., Ballard, C., Hansson, O., Palmqvist, S., Minthon, L., Aarsland, D., Londos, E.

Objective: This 30-week extension trial was a continuation of the first double-blind randomized controlled trial (RCT) to study memantine in dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD). The objective was to evaluate the presence of recurrence of symptoms upon drug withdrawal. Furthermore, the aim was to explore washout dynamics in order to […]