Phillips, Michelle A., Childs, Caroline E., Calder, Philip C., Rogers, Peter J.

Findings from epidemiological and observational studies have indicated that diets high in omega-3 polyunsaturated fatty acids (PUFAs) such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) may reduce the risk of cognitive decline and Alzheimer’s disease (AD). To determine if increasing intake of DHA and EPA through supplementation is beneficial to cognition and mood in […]

Freund-Levi, Yvonne, Hjorth, Erik, Lindberg, Catharina, Cederholm, Tommy, Faxén-Irving, Gerd, Vedin, Inger, Palmblad, Jan, Wahlund, Lars-Olof, Schultzberg, Marianne, Basun, Hans, Eriksdotter-Jönhagen, Maria

Background: omega-3 fatty acids (omega-3 FAs) found in dietary fish or fish oils are anti-inflammatory agents that may influence Alzheimer’s disease (AD).; Objective: To study the effects of dietary omega-3 FA supplementation on inflammatory markers in cerebrospinal fluid (CSF) and plasma from patients with mild to moderate AD.; Methods: Thirty-five patients (70.3 +/- 8.2 years) […]

Shinto, Lynne, Quinn, Joseph, Montine, Thomas, Dodge, Hiroko H., Woodward, William, Baldauf-Wagner, Sara, Waichunas, Dana, Bumgarner, Lauren, Bourdette, Dennis, Silbert, Lisa, Kaye, Jeffrey

Oxidative stress, inflammation, and increased cholesterol levels are all mechanisms that have been associated with Alzheimer’s disease (AD) pathology. Several epidemiologic studies have reported a decreased risk of AD with fish consumption. This pilot study was designed to evaluate the effects of supplementation with omega-3 fatty acids alone (ω-3) or omega-3 plus alpha lipoic acid […]

Faxén Irving, Gerd, Freund-Levi, Yvonne, Eriksdotter-Jönhagen, Maria, Basun, Hans, Brismar, Kerstin, Hjorth, Erik, Palmblad, Jan, Vessby, Bengt, Vedin, Inger, Wahlund, Lars-Olof, Cederholm, Tommy

Objectives: To study the effects of omega (Omega)-3 fatty acid (FA) supplements on weight and appetite in patients with mild to moderate Alzheimer’s disease (AD) in relation to inflammatory biomarkers and apolipoprotein E epsilon4 (APOEepsilon4).; Design: Randomized, double-blind, placebo-controlled trial.; Setting: Specialist memory clinics in the Stockholm catchment area.; Participants: Two hundred four patients (aged […]

Faxén-Irving, Gerd, Freund-Levi, Yvonne, Eriksdotter-Jönhagen, Maria, Basun, Hans, Hjorth, Erik, Palmblad, Jan, Vedin, Inger, Cederholm, Tommy, Wahlund, Lars-Olof

Transthyretin (TTR) binds amyloid-β (Aβ) and may reduce brain Aβ, a pathological feature in Alzheimer’s disease (AD). N – 3 fatty acids (FA), docosahexaenoic (DHA), and eicosapentaenoic acid (EPA) may increase TTR transcription in rat hippocampus. We studied effects of n – 3 FA supplementation on TTR-levels in patients with AD. Outpatients were randomized to […]