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Effects of omega-3 fatty acids on inflammatory markers in cerebrospinal fluid and plasma in Alzheimer’s disease: the OmegAD study


Freund-Levi, Yvonne, Hjorth, Erik, Lindberg, Catharina, Cederholm, Tommy, Faxén-Irving, Gerd, Vedin, Inger, Palmblad, Jan, Wahlund, Lars-Olof, Schultzberg, Marianne, Basun, Hans, Eriksdotter-Jönhagen, Maria


Dementia And Geriatric Cognitive Disorders, Volume: 27, No.: 5, Pages.: 481-490

Year of Publication



Background: omega-3 fatty acids (omega-3 FAs) found in dietary fish or fish oils are anti-inflammatory agents that may influence Alzheimer’s disease (AD).; Objective: To study the effects of dietary omega-3 FA supplementation on inflammatory markers in cerebrospinal fluid (CSF) and plasma from patients with mild to moderate AD.; Methods: Thirty-five patients (70.3 +/- 8.2 years) were randomized to a daily intake of 2.3 g omega-3 FAs or placebo for 6 months. The inflammatory markers interleukin (IL)-6, tumour necrosis factor-alpha and soluble interleukin-1 receptor type II (sIL-1RII) were analysed in CSF and plasma at baseline and at 6 months. The AD markers tau-protein, hyperphosphorylated tau-protein and beta-amyloid (Abeta(1-42)) were assessed in CSF. High-sensitivity C-reactive protein was assessed in plasma. A possible relation to the APOE genotype was investigated.; Results: There was no significant treatment effect of omega-3 FAs on inflammatory and AD biomarkers in CSF or on inflammatory markers in plasma, nor was there any relation with APOE. A significant correlation was observed at baseline between sIL-1RII and Abeta(1-42) levels in CSF.; Conclusions: Treatment of AD patients with omega-3 FAs for 6 months did not influence inflammatory or biomarkers in CSF or plasma. The correlation between sIL-1RII and Abeta(1-42) may reflect the reciprocal interactions between IL-1 and Abeta peptides.;

Bibtex Citation

@article{Freund_Levi_2009, doi = {10.1159/000218081}, url = {}, year = 2009, publisher = {S. Karger {AG}}, volume = {27}, number = {5}, pages = {481--490}, author = {Yvonne Freund-Levi and Erik Hjorth and Catharina Lindberg and Tommy Cederholm and Gerd Faxen-Irving and Inger Vedin and Jan Palmblad and Lars-Olof Wahlund and Marianne Schultzberg and Hans Basun and Maria Eriksdotter J{&}ouml$mathsemicolon$nhagen}, title = {Effects of Omega-3 Fatty Acids on Inflammatory Markers in Cerebrospinal Fluid and Plasma in Alzheimer{&}rsquo$mathsemicolon$s Disease: The {OmegAD} Study}, journal = {Dementia and Geriatric Cognitive Disorders} }


3, acids, aged, alzheimer disease, apolipoproteins e, biological markers, blood, cerebrospinal fluid, cytokines, dietary supplements, double-blind method, fatty, female, genetics, genotype, humans, inflammation, male, neuropsychological tests, omega, outcomes, tau proteins, test, therapeutic use

Countries of Study


Types of Dementia

Alzheimer’s Disease

Types of Study

Randomised Controlled Trial

Type of Outcomes


Type of Interventions

Pharmaceutical Interventions

Pharmaceutical Interventions

Herbal remedies, vitamins, dietary supplements