This database contains 142 studies, archived under the term: "Non randomised controlled trial"
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Reduced TNF-α and increased IGF-I levels in the serum of Alzheimer’s disease patients treated with the neurotrophic agent cerebrolysin
Alvarez, X. Anton,
Sampedro, Carolina,
Cacabelos, Ramon,
Linares, Carlos,
Aleixandre, Manuel,
García-Fantini, Manuel,
Moessler, Herbert
According to current scientific knowledge, excess tumour necrosis factor-α (TNF-α) and low insulin-like growth factor-I (IGF-I) are pathogenic-risk factors that constitute therapeutic targets for Alzheimer’s disease (AD). Changes in serum TNF-α, total and dissociable IGF-I levels were determined by ELISA in 207 AD patients completing a 24-wk, double-blind, placebo-controlled trial to evaluate the effects of […]
Effect of music on pain for home-dwelling persons with dementia
The purpose of this study was to investigate the effect of music on pain for home-dwelling persons with dementia. A quasiexperimental design was used. Fifteen subjects listened to their preferred music for 30 minutes before peak agitation time, for 2 days per week, followed by no music for 2 weeks. The process was repeated once. […]
Safety and tolerability of rivastigmine capsule with memantine in patients with probable Alzheimer’s disease: a 26-week, open-label, prospective trial (Study ENA713B US32)
Olin, Jason T.,
Bhatnagar, Vinod,
Reyes, Patricio,
Koumaras, Barbara,
Meng, Xiangyi,
Brannan, Stephen
Objective: Rivastigmine, a dual cholinesterase inhibitor (ChEI), is widely approved for the symptomatic treatment of both mild-to-moderate Alzheimer’s disease (AD) and Parkinson’s disease dementia. Orally administered ChEIs may be associated with gastrointestinal (GI) side effects and add-on therapy with memantine, an N-methyl-d-aspartate receptor antagonist, approved for moderate-to-severe AD, may ameliorate such side effects. This was […]
Urine neural thread protein measurements in Alzheimer disease
Objectives: Neural thread protein (NTP), a membrane-associated phosphoprotein, was selectively elevated in the urine of patients with Alzheimer disease (AD). To demonstrate the potential utility of urine NTP assays for the diagnosis of AD, we performed this study.; Design: A prospective blinded multicentered study.; Participants: Individuals diagnosed as having probable AD (n = 49), Parkinson’s […]
Quality of life of residents with dementia in traditional versus small-scale long-term care settings: a quasi-experimental study
de Rooij, Alida H. P. M.,
Luijkx, Katrien G.,
Schaafsma, Juliette,
Declercq, Anja G.,
Emmerink, Peggy M. J.,
Schols, Jos M. G. A.
Background: The number of people living with dementia worldwide is increasing, resulting in a need for more residential care. In response to criticism of the traditional medical approach to residential dementia care, many large nursing homes are transforming their traditional care facilities into more home-like small-scale living facilities.; Objectives: This study examined the assumed benefits […]
Implementatie, effecten en kosten van casemanagement voor mensen met dementie en hun mantelzorgers: Beschrijving van de COMPAS studie. = Comparing case management care models for people with dementia and their caregivers: The design of the COMPAS study
van Hout, H. P. J.,
Macneil Vroomen, J. L.,
Van Mierlo, L. D.,
Meiland, F. J. M.,
Moll van Charante, E. P.,
Joling, K. J.,
van den Dungen, P.,
Dröes, R. M.,
van der Horst, H. E.,
de Rooij, S. E. J. A.
Background: Dementia care in The Netherlands is shifting from fragmented, ad hoc care to more coordinated and personalized care. Case management contributes to this shift. The linkage model and a combination of intensive case management and joint agency care models were selected based on their emerging prominence in The Netherlands. It is unclear if these […]
Comparing Dutch case management care models for people with dementia and their caregivers: The design of the COMPAS study.
MacNeil Vroomen, Janet,
Van Mierlo, Lisa D.,
van de Ven, Peter M.,
Bosmans, Judith E,
van den Dungen, Pim,
Meiland, Franka J. M.,
Dröes, Rose-Marie,
Moll van Charante, Eric P.,
van der Horst, Henriëtte E,
de Rooij, Sophia E.,
van Hout, Hein P.J.
Background: Dementia care in the Netherlands is shifting from fragmented, ad hoc care to more coordinated and personalised care. Case management contributes to this shift. The linkage model and a combination of intensive case management and joint agency care models were selected based on their emerging prominence in the Netherlands. It is unclear if these […]