This database contains 140 studies, archived under the term: "Depression and Anxiety"
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Rivastigmine for mild cognitive impairment in Parkinson disease: a placebo-controlled study
Mild cognitive impairment (MCI) in Parkinson’s disease (PD) may be associated with subtle functional impairment and worse quality of life. The objective of this study was to determine the efficacy and tolerability of rivastigmine for PD-MCI. Patients with PD-MCI (n = 28) were enrolled in a 24-week, randomized, double-blind, placebo-controlled, crossover, single-site study of the rivastigmine transdermal […]
Effectiveness of an individualized functional training program on affective disturbances and functional skills in mild and moderate dementia—A randomized control trial
Lam, Linda C. W.,
Lui, Victor W. C.,
Luk, Daisy N. Y.,
Chau, Rachel,
So, Clifton,
Poon, Vickie,
Tam, Peter,
Ching, Raymond,
Lo, Henry,
Chiu, Julian,
Fung, Ada,
Ko, Flora S. L.
Objectives: We reported the findings of a randomized controlled trial (RCT) to examine the effects of an individualized functional enhancement program (FEP) on functional skills and mood symptoms in mild and moderate dementia. Subjects & Methods: 74 Chinese older persons with dementia were recruited into a skills training program by occupational therapists (OT). Thirty seven […]
Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: A randomized trial
Lautenschlager, Nicola T.,
Cox, Kay L.,
Flicker, Leon,
Foster, Jonathan K.,
van Bockxmeer, Frank M.,
Xiao, Jianguo,
Greenop, Kathryn R.,
Almeida, Osvaldo P.
Context: Many observational studies have shown that physical activity reduces the risk of cognitive decline; however, evidence from randomized trials is lacking. Objective: To determine whether physical activity reduces the rate of cognitive decline among older adults at risk. Design and Setting: Randomized controlled trial of a 24-week physical activity intervention conducted between 2004 and […]
Musical structural determinants of emotional judgments in dementia of the Alzheimer type
People with dementia of the Alzheimer type (DAT) may well be emotionally soothed by listening to music. However, very few systematic studies have been conducted to support the anecdotal evidence. DAT does damage certain cerebral structures that subsume emotional processing, and some studies have demonstrated deficits affecting emotional judgments of facial expression and prosody in […]
Long-term treatment of patients with Alzheimer’s disease in primary and secondary care: Results from an international survey
Froelich, Lutz,
Andreasen, Niels,
Tsolaki, Magda,
Foucher, Arnaud,
Kavanagh, Shane,
Van Baelen, Bart,
Schwalen, Susanne
Objective: The International Outcomes Survey in Dementia (IOSID) was initiated to observe the effects of current standard of care for Alzheimer’s disease (AD) on patient outcomes and caregiver burden in a real-life setting. Research design and methods: This 2-year, international, prospective, longitudinal and observational cohort survey involved patients with mild-to-moderate AD (Mini-Mental State Examination [MMSE] […]