Carrasco, Manuel Martin, Agüera, Luis, Gil, Pedro, Moríñigo, Angel, Leon, Teresa

The objective of this study was to evaluate the prevalence and treatment responsiveness of neuropsychiatric symptoms in patients with mild to moderately severe Alzheimer disease recruited in a naturalistic treatment setting in Spain. All the patients, who matched the prescribing recommendations for donepezil and were able to participate in the study, received donepezil (5 to […]

Brodaty, Henry, Mittelman, Mary, Gibson, Louisa, Seeher, Katrin, Burns, Alistair

Objective: Does psychosocial intervention for caregivers whose spouses with Alzheimer disease (AD) are taking donepezil delay nursing home (NH) placement or death of patients?; Design: Randomized controlled trial with 2 years of active treatment and up to 8.5 years of follow-up (mean: 5.4 years, SD: 2.4).; Setting: Outpatients of research clinics in Australia, the United […]

Braun, Melanie, Scholz, Urte, Hornung, Rainer, Martin, Mike

Objectives: Despite a rapid increase in studies dealing with dementia caregivers in Europe, a valid German version of the most widely used measurement of caregiver burden (Zarit Burden Interview) has not yet been published. The purpose of this study is to evaluate the psychometric properties of the German Zarit Burden Interview (G-ZBI).; Method: Twenty-eight community-dwelling […]

Banningh, L. W. A. J.-W., Vernooij-Dassen, M. J. F. J., Vullings, M., Prins, J. B., Rikkert, M. G. M. O., Kessels, R. P. C.

This controlled study examines the efficacy of a comprehensive group program aimed at care partners of patients with mild cognitive impairment (MCI), which comprises elements of psychoeducation, cognitive rehabilitation, and cognitive behavioral therapy. Pre- and posttreatment quantitative and qualitative data were collected in the significant others of 84 patients with MCI, 27 of whom had […]

Ballard, Clive, Hanney, Maria Luisa, Theodoulou, Megan, Douglas, Simon, McShane, Rupert, Kossakowski, Katja, Gill, Randeep, Juszczak, Edmund, Yu, Ly-Mee, Jacoby, Robin

Background: Data from 12-week placebo-controlled trials have led to mounting concerns about increased mortality in patients with Alzheimer’s disease (AD) who are prescribed antipsychotics; however, there are no mortality data from long-term placebo-controlled trials. We aimed to assess whether continued treatment with antipsychotics in people with AD is associated with an increased risk of mortality.; […]

Attanasio, A., Bedin, M., Stocco, S., Negrin, V., Biancon, A., Cecchetto, G., Tagliapietra, M.

Aim: Several reviews or clinical trials published in the last years have not demonstrated that tube feeding can improve outcomes, including inhalation pneumonia, survival, pressure sores. Further, high rate of risks are recognized. Therefore, this practice should be discouraged for severely demented patients. The aim of this study was to assess the validity of these […]