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Rivastigmine patch ameliorates depression in mild AD: Preliminary evidence from a 6-month open-label observational study


Spalletta, Gianfranco, Gianni, Walter, Giubilei, Franco, Casini, Anna R., Sancesario, Giuseppe, Caltagirone, Carlo, Cravello, Luca


Alzheimer Disease and Associated Disorders, Volume: 27, No.: 3, Pages.: 289-291

Year of Publication



Here we investigated the effect of the rivastigmine patch alone on depression in 50 mild Alzheimer’s Disease (AD) patients with comorbid major depressive episode (MDE). First diagnosis acetyl-cholinesterase inhibitor and psychoactive drug-free outpatients (n = 50) were recruited in memory clinics and reassessed after 3 and 6 months. Global cognitive functioning, depressive symptoms and MDE frequency were evaluated with the Mini Mental State Examination, the CERAD Dysphoria scale and the modified DSM-IV criteria for MDE in AD. MDE frequency reduced significantly from the first diagnostic visit (100%) to the 6-month follow-up (62%). We also found a significant reduction in CERAD Dysphoria scores that decreased from 6.2 ± 3.9 mean±standard deviation to 4.9 ± 4.5 at the 6-month follow-up. In AD patients with MDE rivastigmine alone can have a positive impact on depressive phenomena. Thus, future controlled study are justified to definitively verify if rivastigmine alone may improve depression in AD. (PsycINFO Database Record (c) 2013 APA, all rights reserved). (journal abstract)


alzheimer’s disease, comorbidity, drug therapy, drug treatment, major depression, mild alzheimers disease, rivastigmine, rivistigimine

Countries of Study


Types of Dementia

Alzheimer’s Disease

Types of Study

Before and After Study

Type of Outcomes

Cognition, Depression and Anxiety


Specialist Dementia Centre Care / Memory Clinic

Type of Interventions

Pharmaceutical Interventions

Pharmaceutical Interventions

Anti-Alzheimer medications, e.g.: donezepil, galantamine, rivastigmine, memantime