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Persistence of the effects of Cerebrolysin on cognition and qEEG slowing in vascular dementia patients: results of a 3-month extension study


Muresanu, Dafin F., Alvarez, X. Anton, Moessler, Herbert, Novak, Philipp H., Stan, Adina, Buzoianu, Anca, Bajenaru, Ovidiu, Popescu, Bogdan O.


Journal Of The Neurological Sciences, Volume: 299, No.: 1-2, Pages.: 179-183

Year of Publication



The maintenance of the effects of Cerebrolysin, a peptidergic compound with neurotrophic activity, on cognitive performance and qEEG activity was investigated through a 12-week, open-label extension of a 4-week, randomised, placebo-controlled pilot study. Thirty-three out of 41 patients with mild-to-moderate severe probable vascular dementia (VaD) according to NINDS-AIREN participating in the double-blind phase of the study were also assessed at the follow-up visit at week 16. Patients received i.v. infusions of Cerebrolysin (10 or 30 mL) or placebo (saline) 5 days/week for 4 weeks. Neuropsychological evaluations and qEEG recordings were done at baseline, week 4 and week 16. The mean change in score from baseline in the ADAS-cog+ and the slow-to-fast qEEG power ratio (PR), used as an index of qEEG slowing, were the two primary endpoints. Correlations between changes in cognition and qEEG induced by the treatment were also assessed. At the week 16 follow-up visit, Cerebrolysin improved (p<0.05) cognitive performance at the 10-mL and 30-mL doses and reduced qEEG slowing significantly (p<0.05) at the 30-mL dose with respect to the placebo. In addition, a significant (p<0.05) positive correlation between the change from the baseline qEEG PR and ADAS-cog+ variables was observed at week 16. These results indicate a persistence of the beneficial effects of Cerebrolysin on cognition and qEEG activity in VaD patients for at least 12 weeks after treatment cessation, and they suggest the potential utility of qEEG parameters as biomarkers for VaD clinical trials.; Copyright © 2010 Elsevier B.V. All rights reserved.

Bibtex Citation

@article{Muresanu_2010, doi = {10.1016/j.jns.2010.08.040}, url = {}, year = 2010, month = {dec}, publisher = {Elsevier {BV}}, volume = {299}, number = {1-2}, pages = {179--183}, author = {Dafin F. Muresanu and X. Anton Alvarez and Herbert Moessler and Philipp H. Novak and Adina Stan and Anca Buzoianu and Ovidiu Bajenaru and Bogdan O. Popescu}, title = {Persistence of the effects of Cerebrolysin on cognition and {qEEG} slowing in vascular dementia patients: Results of a 3-month extension study}, journal = {Journal of the Neurological Sciences} }


aged, aged, 80 and over, amino acids, analysis of variance, brain, brain mapping, cerebrolysin, cognition, dementia vascular, double-blind method, drug effects, drug therapy, electroencephalography, female, humans, male, middle aged, neuropsychological tests, nootropic agents, qeeg, severity of illness index, therapeutic use, treatment outcome

Countries of Study


Types of Dementia

Vascular Dementia

Types of Study

Randomised Controlled Trial

Type of Outcomes

Cognition, Other

Type of Interventions

Pharmaceutical Interventions

Pharmaceutical Interventions