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Memantine and functional communication in Alzheimer’s disease: results of a 12-week, international, randomized clinical trial


Saxton, Judith, Hofbauer, Robert K., Woodward, Michael, Gilchrist, Nigel L., Potocnik, Felix, Hsu, Hai-An, Miller, Michael L., Pejović, Vojislav, Graham, Stephen M., Perhach, James L.


Journal Of Alzheimer's Disease: JAD, Volume: 28, No.: 1, Pages.: 109-118

Year of Publication



Post hoc analyses suggest that memantine treatment may provide communication-related benefits in patients with Alzheimer’s disease (AD). In this 12-week, international, randomized, double-blind, placebo-controlled trial of memantine (10 mg bid), the functional communication abilities of patients with AD (MMSE range: 10-19) were assessed using the Functional Linguistic Communication Inventory (FLCI; primary measure). Two combined subscales (Social Communication and Communication of Basic Needs) from the American Speech-Language-Hearing Association Functional Assessment of Communication Skills for Adults (ASHA FACS; secondary measure) were administered to caregivers. Treatment-emergent adverse events were also recorded. After 12 weeks, memantine-treated patients (n = 133) demonstrated a non-significant improvement on the FLCI (placebo: -0.6; memantine: 0.7; p = 0.070, LOCF) and a significant improvement on the ASHA FACS (placebo: -5.3; memantine: 0.5; p = 0.022), compared with placebo-treated patients (n = 124). Memantine had a low incidence of adverse events. In patients with moderate AD, memantine treatment improved functional communication, as recognized by caregivers.;


activities of daily living, aged, aged, 80 and over, alzheimer disease, communication, double-blind method, drug therapy, female, humans, internationality, male, memantine, neuropsychological tests, psychology, therapeutic use

Countries of Study


Types of Dementia

Alzheimer’s Disease

Types of Study

Randomised Controlled Trial

Type of Outcomes


Type of Interventions

Pharmaceutical Interventions

Pharmaceutical Interventions

Anti-Alzheimer medications, e.g.: donezepil, galantamine, rivastigmine, memantime