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Levodopa use and sleep in patients with dementia with Lewy bodies


Molloy, Sophie, Minett, Thais, O'Brien, John T, McKeith, Ian G, Burn, David J.


Movement Disorders: Official Journal Of The Movement Disorder Society, Volume: 24, No.: 4, Pages.: 609-612

Year of Publication



Sleep disturbance and excessive daytime somnolence (EDS) are features of Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) that may be influenced by dopamine replacement therapy. The effect of levodopa on sleep and EDS in DLB is unknown and unclear in PD. The aim of this study is to determine if levodopa treatment alters sleep symptoms and EDS in DLB. Dopamine naïve patients with DLB (n = 15; mean mini mental state examination (MMSE) score 17.7(4.6)) and PD (n = 9; mean MMSE 25.5(2.2)) were assessed using the Epworth sleep scale, Parkinson’s disease sleep scale, and the neuropsychiatric inventory prior to initiating treatment with levodopa. All measures were repeated after 3 and 6 months of levodopa therapy. The median final daily levodopa dose was 300 mg in both groups. Baseline sleep measures were comparable between groups. Levodopa treatment did not affect sleep or lead to increased EDS in DLB patients. The use of levodopa does not appear to adversely affect subjective sleep measures or increase EDS in DLB patients.;

Bibtex Citation

@article{Molloy_2009, doi = {10.1002/mds.22411}, url = {}, year = 2009, month = {mar}, publisher = {Wiley-Blackwell}, volume = {24}, number = {4}, pages = {609--612}, author = {Sophie Molloy and Thais Minett and John T. O{textquotesingle}Brien and Ian G. McKeith and David J. Burn}, title = {Levodopa use and sleep in patients with dementia with Lewy bodies}, journal = {Movement Disorders} }


aged, aged, 80 and over, antiparkinson agents, complications, drug therapy, etiology, female, humans, levodopa, lewy body disease, male, mental status schedule, parkinson disease, questionnaires, severity of illness index, sleep, sleep disorders, therapeutic use, time factors

Countries of Study


Types of Dementia

Lewy-Body, Parkinson’s Dementia

Types of Study

Before and After Study

Type of Outcomes

Behaviour, Other

Type of Interventions

Pharmaceutical Interventions

Pharmaceutical Interventions