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Levodopa response in dementia with lewy bodies: a 1-year follow-up study


Lucetti, Claudio, Logi, Chiara, Del Dotto, Paolo, Berti, Caterina, Ceravolo, Roberto, Baldacci, Filippo, Dolciotti, Cristina, Gambaccini, Gianna, Rossi, Giuseppe, Bonuccelli, Ubaldo


Parkinsonism & Related Disorders, Volume: 16, No.: 8, Pages.: 522-526

Year of Publication



Purpose: To evaluate levodopa responsiveness in patients with probable dementia with Lewy bodies (DLB) compared to early Parkinson’s disease (PD) patients.; Methods: Twenty four cases with DLB and 21 with PD underwent a baseline assessment with UPDRS (sub-item II and III) and an acute levodopa challenge test. Positive response to acute levodopa test was defined as an improvement of at least 15% in the tapping test, and at least 25% in the walking test and rigidity or tremor score. Subsequently, all patients were treated continuously with levodopa and evaluated after 6 and 12 months by means of UPDRS II/III.; Results: Positive response to the acute levodopa test was observed in 55% of DLB patients (acute DLB responders), and in 90% of PD patients (acute PD responders). Acute DLB responders showed increased latency, and reduction of both duration and amplitude of response to acute levodopa in comparison with acute PD responders. At the 6-month follow-up visit, acute DLB responders showed a greater motor benefit compared with acute DLB non-responders. This improvement was similar to that observed in PD patients. However, at 1-year follow-up acute DLB responders showed a faster worsening of UPDRS III scores compared with acute PD responders, implying a reduction of levodopa efficacy.; Conclusions: Positive response to acute levodopa test can occur in DLB patients and may be predictive of long-term benefit of chronic levodopa therapy, although the motor improvement is less impressive than in PD patients.; Copyright © 2010. Published by Elsevier Ltd.

Bibtex Citation

@article{Lucetti_2010, doi = {10.1016/j.parkreldis.2010.06.004}, url = {}, year = 2010, month = {sep}, publisher = {Elsevier {BV}}, volume = {16}, number = {8}, pages = {522--526}, author = {Claudio Lucetti and Chiara Logi and Paolo Del Dotto and Caterina Berti and Roberto Ceravolo and Filippo Baldacci and Cristina Dolciotti and Gianna Gambaccini and Giuseppe Rossi and Ubaldo Bonuccelli}, title = {Levodopa response in dementia with lewy bodies: A 1-year follow-up study}, journal = {Parkinsonism {&} Related Disorders} }


aged, and, antiparkinson agents, drug therapy, female, functions, humans, levodopa, lewy body disease, male, mobility, motor, parkinson disease, therapeutic use

Countries of Study


Types of Dementia

Lewy-Body, Parkinson’s Dementia

Types of Study

Randomised Controlled Trial

Type of Outcomes


Type of Interventions

Pharmaceutical Interventions

Pharmaceutical Interventions