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Increased masticatory activity and quality of life in elderly persons with dementia–a longitudinal matched cluster randomized single-blind multicenter intervention study


Weijenberg, Roxane Anthea Francesca, Lobbezoo, Frank, Knol, Dirk Lucas, Tomassen, Jori, Scherder, Erik Johan Anton


BMC Neurology, Volume: 13, Pages.: 26-26

Year of Publication



Background: Worldwide, millions of people are suffering from dementia and this number is rising. An index of quality of life (QoL) can describe the impact a disease or treatment has on a person’s wellbeing. QoL comprises many variables, including physical health and function, and mental health and function. QoL is related to masticatory ability and physical activity. Animal studies show that disruption of mastication due to loss of teeth or a soft diet leads to memory loss and learning problems. Since these are common complaints in dementia, it is hypothesized that improvement of masticatory function and normalization of diet consistency can increase QoL in elderly persons suffering from dementia. Therefore, the goal of the present study is to examine whether an increase in masticatory activity, achieved by increased food consistency and enhancement of masticatory function through improved oral health care has a positive effect on QoL, including cognition, mood, activities of daily living (ADL), and circadian rhythm in elderly persons with dementia.; Methods and Design: The described study is a prospective longitudinal matched cluster randomized single-blind multicenter study. Participants are elderly persons living in the Netherlands, suffering from dementia and receiving psychogeriatric care. An intervention group will receive improved oral health care and a diet of increased consistency. A control group receives care as usual. Participants will be assessed four times; outcome variables besides QoL are cognition, mood, independence, rest-activity rhythm, blood pressure, and masticatory function.; Discussion: This research protocol investigates the effect of an intervention executed by daily caregivers. The intervention will increase masticatory activity, which is achieved by three different actions, (providing oral health care, increasing food consistency, or a combination of both). There is a certain amount of variety in the nature of the interventions due to local differences in nursing homes. This might be a scientific weakness in the study design; however, a practical implementation of any findings will be subject to the same factors, making this study design clinically relevant.; Trial Registration: NTR1561.;

Bibtex Citation

@article{Weijenberg_2013, doi = {10.1186/1471-2377-13-26}, url = {}, year = 2013, month = {mar}, publisher = {Springer Nature}, volume = {13}, number = {1}, author = {Roxane Anthea Francesca Weijenberg and Frank Lobbezoo and Dirk Lucas Knol and Jori Tomassen and Erik Johan Anton Scherder}, title = {Increased masticatory activity and quality of life in elderly persons with dementia-a longitudinal matched cluster randomized single-blind multicenter intervention study}, journal = {{BMC} Neurology} }


a, activities of daily living, aged, aged, 80 and over, and, blood, blood pressure, care, cognition disorders, consistency, dementia, diet, etiology, exercise therapy, female, function, health, humans, increased, longitudinal studies, male, mastication, memory disorders, methods, neuropsychological tests, of, oral, physiology, physiopathology, pressure, psychology, quality of life, rehabilitation, verbal learning, visual perception

Countries of Study


Types of Dementia

Dementia (general / unspecified)

Types of Study

Randomised Controlled Trial

Type of Outcomes

ADLs/IADLs, Cognition, Other, Quality of Life of Person With Dementia


Nursing Homes

Type of Interventions

Non-pharmacological Treatment

Non-Pharmaceutical Interventions