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Evaluation of the convenience of changing the rivastigmine administration route in patients with Alzheimer disease


Blesa González, R., Boada Rovira, M., Martínez Parra, C., Gil-Saladié, D., Almagro, C. A., Gobartt Vázquez, A. L.


Neurología (Barcelona, Spain), Volume: 26, No.: 5, Pages.: 262-271

Year of Publication



Introduction: Rivastigmine transdermal patches for the treatment of Alzheimer’s disease (AD) have potential benefits compared to capsules because of their sustained absorption through the skin, good local tolerability and reduction of gastrointestinal problems.; Purpose: To assess gastrointestinal and skin tolerability and the need for optimal dose titration of rivastigmine transdermal patches in Alzheimer’s disease patients previously treated with oral rivastigmine.; Patients and Methods: A multicenter, randomized, open-label study including patients with mild to moderate AD (DSM-IV) previously treated with rivastigmine capsules (6-12 mg/day) was conducted. Patients were randomized to: continue with capsules for 3 months (n=49) or switch to rivastigmine patch without titration (9.5mg/day for 3 months; n=48), or switch to rivastigmine patch with titration (4.6 mg/day for 1 month followed by 9.5mg/day for 2 months, n=43).; Results: Incidence of gastrointestinal adverse events was 6.1% in the group treated orally and 4.2% in the group treated with non-titrated patches (P=.908). Skin tolerability was good (n=15, 16.7%) without any serious adverse events registered. Patch treatment was considered very easy to use by 72% of patients compared with 30% in the group with oral treatment (P=.0005). 60% of patients were satisfied with the patch, while only 14% were satisfied with capsules (P<.0001).; Conclusions: Rivastigmine patches have a tolerability profile similar to that shown by capsules, but are associated with greater patient satisfaction.; Copyright © 2010 Sociedad Española de Neurología. Published by Elsevier Espana. All rights reserved.

Bibtex Citation

@article{Blesa_Gonz_lez_2011, doi = {10.1016/j.nrl.2010.10.007}, url = {}, year = 2011, month = {jun}, publisher = {Elsevier {BV}}, volume = {26}, number = {5}, pages = {262--271}, author = {R. Blesa Gonz{'{a}}lez and M. Boada Rovira and C. Mart{'{i}}nez Parra and D. Gil-Saladi{'{e}} and C.A. Almagro and A.L. Gobartt V{'{a}}zquez}, title = {Evaluaci{'{o}}n de la conveniencia del cambio de v{'{i}}a de administraci{'{o}}n de rivastigmina en pacientes con enfermedad de Alzheimer}, journal = {Neurolog{'{i}}a} }


administration & dosage, administration cutaneous, administration oral, adverse, aged, alzheimer disease, cholinesterase inhibitors, drug therapy, events, female, humans, male, medication, phenylcarbamates, rivastigmine, tolerability

Countries of Study


Types of Dementia

Alzheimer’s Disease

Types of Study

Randomised Controlled Trial

Type of Outcomes


Type of Interventions

Pharmaceutical Interventions

Pharmaceutical Interventions

Anti-Alzheimer medications, e.g.: donezepil, galantamine, rivastigmine, memantime