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CSF α-synuclein concentrations do not fluctuate over hours and are not correlated to amyloid β in humans

Authors

Spies, Petra E., Slats, Diane, Olde Rikkert, Marcel G. M., Tseng, Jack, Claassen, Jurgen A. H. R., Verbeek, Marcel M.

Journal

Neuroscience Letters, Volume: 504, No.: 3, Pages.: 336-338

Year of Publication

2011

Abstract

Reports on the value of cerebrospinal fluid (CSF) α-synuclein as a biomarker for dementia with Lewy bodies and Parkinson disease are contradicting. This may be explained by fluctuating CSF α-synuclein concentrations over time. Such fluctuations have been suggested for CSF amyloid β concentrations. Furthermore, a physiological relationship between α-synuclein and amyloid β has been suggested based on in vitro research. We performed repeated CSF sampling in healthy elderly and AD patients and showed that sinusoidal fluctuations in CSF α-synuclein concentrations were not present. Furthermore, we did not find evidence for an interaction between amyloid β and α-synuclein concentrations in CSF.; Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

Bibtex Citation

@article{Spies_2011, doi = {10.1016/j.neulet.2011.09.063}, url = {http://dx.doi.org/10.1016/j.neulet.2011.09.063}, year = 2011, month = {oct}, publisher = {Elsevier {BV}}, volume = {504}, number = {3}, pages = {336--338}, author = {Petra E. Spies and Diane Slats and Marcel G.M. Olde Rikkert and Jack Tseng and Jurgen A.H.R. Claassen and Marcel M. Verbeek}, title = {{CSF} $upalpha$-synuclein concentrations do not fluctuate over hours and are not correlated to amyloid $upbeta$ in humans}, journal = {Neuroscience Letters} }

Keywords

aged, aging, alphasynuclein, alzheimer disease, cerebrospinal fluid, diagnosis, female, humans, male, middle aged, models biological, peptide fragments, time factors

Countries of Study

Netherlands

Types of Dementia

Lewy-Body, Parkinson’s Dementia

Types of Study

Randomised Controlled Trial

Type of Outcomes

Other

Type of Interventions

Diagnostic Target Identification

Diagnostic Targets

Biological Testing
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