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Antioxidant effect of astaxanthin on phospholipid peroxidation in human erythrocytes


Nakagawa, Kiyotaka, Kiko, Takehiro, Miyazawa, Taiki, Carpentero Burdeos, Gregor, Kimura, Fumiko, Satoh, Akira, Miyazawa, Teruo


The British Journal Of Nutrition, Volume: 105, No.: 11, Pages.: 1563-1571

Year of Publication



Phospholipid hydroperoxides (PLOOH) accumulate abnormally in the erythrocytes of dementia patients, and dietary xanthophylls (polar carotenoids such as astaxanthin) are hypothesised to prevent the accumulation. In the present study, we conducted a randomised, double-blind, placebo-controlled human trial to assess the efficacy of 12-week astaxanthin supplementation (6 or 12 mg/d) on both astaxanthin and PLOOH levels in the erythrocytes of thirty middle-aged and senior subjects. After 12 weeks of treatment, erythrocyte astaxanthin concentrations were higher in both the 6 and 12 mg astaxanthin groups than in the placebo group. In contrast, erythrocyte PLOOH concentrations were lower in the astaxanthin groups than in the placebo group. In the plasma, somewhat lower PLOOH levels were found after astaxanthin treatment. These results suggest that astaxanthin supplementation results in improved erythrocyte antioxidant status and decreased PLOOH levels, which may contribute to the prevention of dementia.;

Bibtex Citation

@article{Nakagawa_2011, doi = {10.1017/s0007114510005398}, url = {}, year = 2011, month = {jan}, publisher = {Cambridge University Press ({CUP})}, volume = {105}, number = {11}, pages = {1563--1571}, author = {Kiyotaka Nakagawa and Takehiro Kiko and Taiki Miyazawa and Gregor Carpentero Burdeos and Fumiko Kimura and Akira Satoh and Teruo Miyazawa}, title = {Antioxidant effect of astaxanthin on phospholipid peroxidation in human erythrocytes}, journal = {British Journal of Nutrition} }


aged, blood, chemistry, chlorophyta, double-blind method, drug effects, erythrocytes, female, humans, male, metabolism, middle aged, pharmacology, phospholipids, plant oils, xanthophylls

Countries of Study


Types of Study

Randomised Controlled Trial

Type of Interventions

Risk Factor Modification

Risk Factor Modifications

General population health promotion