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A 24-week, multicentre, open evaluation of the clinical effectiveness of the rivastigmine patch in patients with probable Alzheimer’s disease


Articus, K., Baier, M., Tracik, F., Kühn, F., Preuss, U. W., Kurz, A.


International Journal Of Clinical Practice, Volume: 65, No.: 7, Pages.: 790-796

Year of Publication



Background: Cholinesterase inhibitors form the mainstay of treatment for persons with mild-to-moderate Alzheimer’s disease (AD). The rivastigmine patch may increase compliance and the proportion of patients maintaining an efficacious dose compared with oral cholinesterase inhibitors.; Objective: To investigate the proportion of patients who reached and maintained the target rivastigmine patch dose compared with the target rivastigmine capsule dose reported in clinical trials.; Methods: This was a multicentre, 24-week, open-label study in persons with probable AD and a Mini-Mental State Examination (MMSE) score of ≥ 10 and ≤ 26. The primary outcome was the proportion of patients (ITT population) treated with 9.5 mg/24 h rivastigmine patch for at least 8 weeks at week 24. Secondary outcomes included week 24 MMSE, Alzheimer’s Disease Cooperative Study-Clinical Global Impression of Change (ADCS-CGIC), Trail Making Test Part A (TMT-A) and Alzheimer’s Disease Cooperative Study-Activities of Daily Living (ADCS-ADL) scores.; Results: Overall, 208 participants received treatment and 155 (74.5%) completed the study. Within the ITT population, 147/182 patients (80.8%; 95% CI 75.0-86.5%) were treated for at least 8 weeks with the 9.5 mg/24 h rivastigmine patch; 135/182 patients (74.2%; 95% CI 67.8-80.5%) were treated for at least 8 weeks and completed the study. The most common adverse events were nausea (10.1% of patients), erythema (8.7%), pruritus (8.2%) and vomiting (7.2%). At week 24, patients treated with the rivastigmine patch showed improvements on MMSE, ADCS-ADL, ADCS-CGIC and TMT-A scores. Caregivers reported acceptance, preference and satisfaction with the patch.; Conclusion: Transdermal delivery may allow more patients to reach and maintain therapeutic doses of rivastigmine compared with oral rivastigmine.; © 2011 Blackwell Publishing Ltd.

Bibtex Citation

@article{Articus_2011, doi = {10.1111/j.1742-1241.2011.02713.x}, url = {}, year = 2011, month = {jun}, publisher = {Wiley-Blackwell}, volume = {65}, number = {7}, pages = {790--796}, author = {K. Articus and M. Baier and F. Tracik and F. Kühn and U. W. Preu{ss} and A. Kurz}, title = {A 24-week, multicentre, open evaluation of the clinical effectiveness of the rivastigmine patch in patients with probable Alzheimer's disease}, journal = {International Journal of Clinical Practice} }


activities of daily living, adherence, administration & dosage, adverse effects, aged, aged, 80 and over, alzheimer disease, cholinesterase inhibitors, cognition, drug effects, drug therapy, female, humans, male, medication adherence, neuroprotective agents, patch, phenylcarbamates, rivastigmine, transdermal patch, treatment outcome

Countries of Study


Types of Dementia

Alzheimer’s Disease

Types of Study

Before and After Study

Type of Outcomes

ADLs/IADLs, Cognition, Other

Type of Interventions

Pharmaceutical Interventions

Pharmaceutical Interventions

Anti-Alzheimer medications, e.g.: donezepil, galantamine, rivastigmine, memantime