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3D comparison of low, intermediate, and advanced hippocampal atrophy in MCI


Apostolova, Liana G., Thompson, Paul M., Green, Amity E., Hwang, Kristy S., Zoumalan, Charleen, Jack, Clifford R., Jr., Harvey, Danielle J., Petersen, Ronald C., Thal, Leon J., Aisen, Paul S, Toga, Arthur W., Cummings, Jeffrey L., Decarli, Charles S.


Human Brain Mapping, Volume: 31, No.: 5, Pages.: 786-797

Year of Publication



We applied the hippocampal radial atrophy mapping technique to the baseline and follow-up magnetic resonance image data of 169 amnestic mild cognitive impairment (MCI) participants in the imaging arm of the Alzheimer’s Disease Cooperative Study MCI Donepezil/Vitamin E trial. Sixty percent of the subjects with none to mild hippocampal atrophy rated with the visual medial temporal atrophy rating scale (MTA score < 2) and 33.8% of the subjects with moderate to severe (MTA > or = 2) hippocampal atrophy converted to Alzheimer’s disease (AD) during 3-year follow-up. MTA > or = 2 showed a trend for greater left sided hippocampal atrophy versus MTA < 2 groups at baseline (P(corrected) = 0.08). Higher MTA scores were associated with progressive atrophy of the subiculum and the CA1-3 subregions. The MTA < 2 group demonstrated significant bilateral atrophy progression at follow-up (left P(corrected) = 0.008; right P(corrected) = 0.05). Relative to MTA < 2 nonconverters, MTA < 2 converters showed further involvement of the subiculum and CA1 and additional involvement of CA2-3 at follow-up. Right CA1 atrophy was significantly associated with conversion to dementia (for 1 mm greater right CA1 radial distance subjects had 50% reduced hazard for conversion). Greater CA1 and subicular atrophy can be demonstrated early and is predictive of future conversion to AD, whereas CA2-3 involvement becomes more evident as the disease progresses.;

Bibtex Citation

@article{Apostolova_2010, doi = {10.1002/hbm.20905}, url = {}, year = 2010, month = {feb}, publisher = {Wiley-Blackwell}, volume = {31}, number = {5}, pages = {786--797}, author = {Liana G. Apostolova and Paul M. Thompson and Amity E. Green and Kristy S. Hwang and Charleen Zoumalan and Clifford R. Jack and Danielle J. Harvey and Ronald C. Petersen and Leon J. Thal and Paul S. Aisen and Arthur W. Toga and Jeffrey L. Cummings and Charles S. DeCarli}, title = {3D comparison of low, intermediate, and advanced hippocampal atrophy in {MCI}}, journal = {Human Brain Mapping} }


aged, alzheimer disease, atrophy, cognition disorders, diagnostic, disease progression, drug therapy, female, functional laterality, hippocampus, humans, longitudinal studies, magnetic resonance imaging, male, nootropic agents, pathology, severity of illness index, therapeutic use, vitamin e

Countries of Study


Types of Dementia

Mild Cognitive Impairment (MCI)

Type of Outcomes


Type of Interventions

Diagnostic Target Identification

Diagnostic Targets

Neuroimaging (e.g. MRI, PET, CAT etc.)