Cotelli, Maria, Manentil, Rosa, Rosini, Sandra, Brambilla, Michela, Zanetti, Orazio, Miniussi, Carlo

Recent studies have reported enhanced performance on specific cognitive tasks in patients with several types of neurological disease, after receiving non invasive brain stimulation (BS), i.e., repetitive Transcranial Magnetic Stimulation (rTMS) or transcranial Direct Current Stimulation (tDCS) to specific cortical areas. In addition, persistent beneficial effects of off-line rTMS on sentence comprehension in Alzheimer disease […]

Chien, Wai-Tong, Lee, Isabella Y. M.

Aim: This paper reports a study to examine the effectiveness of a 6-month dementia care programme for Chinese families living with and caring for a relative with dementia, compared with routine family support services in Hong Kong. Background: Recognizing the adverse psychosocial health effects inherent in dementia care, different psychosocial interventions provided preliminary evidence of […]

Menn, Petra, Holle, Rolf, Kunz, Simone, Donath, Carolin, Lauterberg, Jörg, Leidl, Reiner, Marx, Peter, Mehlig, Hilmar, Ruckdäschel, Stephan, Vollmar, Horst Christian, Wunder, Sonja, Gräßel, Elmar

Objective: To compare a complex nondrug intervention including actively approaching counseling and caregiver support groups with differing intensity against usual care with respect to time to institutionalization in patients with dementia.; Methods: Within this three-armed cluster-randomized controlled trial, 390 community-dwelling patients aged 65 years or older with physician-diagnosed mild to moderate dementia and their caregivers […]

Bergh, Sverre, Selbaek, Geir, Engedal, Knut

Objective: To determine the effect of discontinuing antidepressant treatment in people with dementia and neuropsychiatric symptoms.; Design: Double blind, randomised, parallel group, placebo controlled trial.; Setting: Norwegian nursing homes; residents recruited by 16 study centres in Norway from August 2008 to June 2010.; Participants: 128 patients with Alzheimer’s disease, dementia or vascular dementia, and neuropsychiatric […]

Scheltens, Philip, Twisk, Jos W.R., Blesa, Rafael, Scarpini, Elio, von Arnim, Christine A. F., Bongers, Anke, Harrison, John, Swinkels, Sophie H. N., Stam, Cornelis J., de Waal, Hanneke, Wurtman, Richard J., Wieggers, Rico L., Vellas, Bruno, Kamphuis, Patrick J. G. H.

Souvenaid aims to improve synapse formation and function. An earlier study in patients with Alzheimer’s disease (AD) showed that Souvenaid increased memory performance after 12 weeks in drug-naïve patients with mild AD. The Souvenir II study was a 24-week, randomized, controlled, double-blind, parallel-group, multi-country trial to confirm and extend previous findings in drug-naïve patients with […]

de Waal, Hanneke, Stam, Cornelis J., Lansbergen, Marieke M., Wieggers, Rico L., Kamphuis, Patrick J. G. H., Scheltens, Philip, Maestú, Fernando, van Straaten, Elisabeth C. W.

Background: Synaptic loss is a major hallmark of Alzheimer’s disease (AD). Disturbed organisation of large-scale functional brain networks in AD might reflect synaptic loss and disrupted neuronal communication. The medical food Souvenaid, containing the specific nutrient combination Fortasyn Connect, is designed to enhance synapse formation and function and has been shown to improve memory performance […]

Aronson, Stephen, Baelen, Bart Van, Kavanagh, Shane, Schwalen, Susanne

Background: Galantamine (hydrobromide), a reversible acetylcholinesterase inhibitor and allosteric nicotinic receptor modulator, slows cognitive and functional decline in mild to moderate dementia of the Alzheimer’s type. Although several drugs are indicated for mild to moderate Alzheimer’s disease (AD), no published study has separately analysed mild and moderate AD subgroups to assess the effect of dosage.; […]