This database contains 15 studies, archived under the term: "specificity"
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A serum protein-based algorithm for the detection of Alzheimer disease
O'Bryant, Sid E.,
Xiao, Guanghua,
Barber, Robert,
Reisch, Joan,
Doody, Rachelle,
Fairchild, Thomas,
Adams, Perrie,
Waring, Steven,
Diaz-Arrastia, Ramon
Objective: To develop an algorithm that separates patients with Alzheimer disease (AD) from controls. Design: Longitudinal case-control study. Setting: The Texas Alzheimer’s Research Consortium project. Patients: We analyzed serum protein-based multiplex biomarker data from 197 patients diagnosed with AD and 203 controls. Main Outcome Measure: The total sample was randomized equally into training and test […]
The Computerized Self Test (CST): An interactive, internet accessible cognitive screening test for dementia
Dougherty, John H., Jr.,
Cannon, Rex L.,
Nicholas, Christopher R.,
Hall, Lorin,
Hare, Felicia,
Carr, Erika,
Dougherty, Andrew,
Janowitz, Jennifer,
Arunthamakun, Justin
The computer self test (CST) is an interactive, internet-based instrument designed to assess functional cognitive domains impaired by Alzheimer’s disease (AD) and mild cognitive impairment (MCI). This study consisted of 215 total subjects with a mean age of 75.24. The 84 cognitively impaired patients (excluding patients diagnosed as MCI) met all criteria set forth by […]
Detecting MCI and dementia in primary care: effectiveness of the MMS, the FAQ and the IQCODE corrected
Cruz-Orduña, Isabel,
Bellón, José M.,
Torrero, Pedro,
Aparicio, Esperanza,
Sanz, Ana,
Mula, Nieves,
Marzana, Garbiñe,
Begué, Concepción,
Cabezón, Dionisio,
Olazarán, Javier
Objectives: To study the yield of three instruments for detection of patients with cognitive impairment in primary care. To investigate whether combining tests is better for detecting impairment than applying them separately.; Methods: Seven primary care physicians (PCP) systematically recruited individuals aged over 49 years with a complaint or suspicion of cognitive impairment. The tests […]
Validation of AclarusDx™, a blood-based transcriptomic signature for the diagnosis of Alzheimer’s disease
Fehlbaum-Beurdeley, Pascale,
Sol, Olivier,
Désiré, Laurent,
Touchon, Jacques,
Dantoine, Thierry,
Vercelletto, Martine,
Gabelle, Audrey,
Jarrige, Anne-Charlotte,
Haddad, Raphaël,
Lemarié, Jean Christophe,
Zhou, Weiyin,
Hampel, Harald,
Einstein, Richard,
Vellas, Bruno
Biomarkers have gained an increased importance in the past years in helping physicians to diagnose Alzheimer’s disease (AD). This study was designed to identify a blood-based, transcriptomic signature that can differentiate AD patients from control subjects. The performance of the signature was then evaluated for robustness in an independent blinded sample population. RNA was extracted […]
Neuroimaging predictors of brain amyloidosis in mild cognitive impairment
Objective: To identify a neuroimaging signature predictive of brain amyloidosis as a screening tool to identify individuals with mild cognitive impairment (MCI) that are most likely to have high levels of brain amyloidosis or to be amyloid-free.; Methods: The prediction model cohort included 62 MCI subjects screened with structural magnetic resonance imaging (MRI) and (11) […]
Brief screening tool for mild cognitive impairment in older Japanese: validation of the Japanese version of the Montreal Cognitive Assessment
Fujiwara, Yoshinori,
Suzuki, Hiroyuki,
Yasunaga, Masashi,
Sugiyama, Mika,
Ijuin, Mutsuo,
Sakuma, Naoko,
Inagaki, Hiroki,
Iwasa, Hajime,
Ura, Chiaki,
Yatomi, Naomi,
Ishii, Kenji,
Tokumaru, Aya M,
Homma, Akira,
Nasreddine, Ziad,
Shinkai, Shoji
Aim: The Montreal Cognitive Assessment (MoCA), developed by Dr Nasreddine (Nasreddine et al. 2005), is a brief cognitive screening tool for detecting older people with mild cognitive impairment (MCI). We examined the reliability and validity of the Japanese version of the MoCA (MoCA-J) in older Japanese subjects.; Methods: Subjects were recruited from the outpatient memory […]
Multivariate spatial covariance analysis of 99mTc-exametazime SPECT images in dementia with Lewy bodies and Alzheimer’s disease: utility in differential diagnosis
Colloby, Sean J,
Taylor, John-Paul,
Davison, Christopher M,
Lloyd, Jim J,
Firbank, Michael J,
McKeith, Ian G,
O'Brien, John T
We examined (99m)Tc-exametazime brain blood flow single-photon emission computed tomography (SPECT) images using a spatial covariance analysis (SCA) approach to assess its diagnostic value in distinguishing dementia with Lewy bodies (DLB) from Alzheimer’s disease (AD). Voxel SCA was simultaneously applied to a set of preprocessed images (AD, n=40; DLB, n=26), generating a series of eigenimages […]
A combination of CSF tau ratio and midsaggital midbrain-to-pons atrophy for the early diagnosis of progressive supranuclear palsy
Borroni, Barbara,
Malinverno, Matteo,
Gardoni, Fabrizio,
Grassi, Mario,
Parnetti, Lucilla,
Agosti, Chiara,
Alberici, Antonella,
Premi, Enrico,
Bonuccelli, Ubaldo,
Gasparotti, Roberto,
Calabresi, Paolo,
Di Luca, Monica,
Padovani, Alessandro
Cerebrospinal fluid (CSF) tau ratio decrease (33kDa/55kDa forms) and mid-saggital midbrain-to-pons (MP) atrophy have been suggested as diagnostic markers for progressive supranuclear palsy (PSP). The usefulness of their combined evaluation has never been tested. We evaluated the CSF tau ratio and the MP atrophy as a combined marker for early identification of PSP. A total […]