This database contains 193 studies, archived under the term: "results"
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A randomized controlled study on effects of ibuprofen on cognitive progression of Alzheimer’s disease
Pasqualetti, Patrizio,
Bonomini, Cristina,
Dal Forno, Gloria,
Paulon, Luca,
Sinforiani, Elena,
Marra, Camillo,
Zanetti, Orazio,
Rossini, Paolo Maria
Background and Aims: Epidemiological studies have examined the association between the use of non-steroidal anti-inflammatory drugs (NSAIDs) and the risk of Alzheimer’s disease (AD). Recently, a variety of experimental studies indicates that a subset of NSAIDs, such as ibuprofen or flurbiprofen, also have Abeta-lowering properties in both AD transgenic mice and cell cultures of peripheral, […]
Effectiveness of a psychoeducational intervention program in the reduction of caregiver burden in Alzheimer’s disease patients’ caregivers
Martín-Carrasco, Manuel,
Martín, Manuel Franco,
Valero, Carmelo Pelegrín,
Millán, Pedro Roy,
García, Celso Iglesias,
Montalbán, Salvador Ros,
Vázquez, Ana Luisa Gobartt,
Piris, Sonia Pons,
Vilanova, Montserrat Balañá
Objectives: Caregivers of patients with Alzheimer’s disease (AD) experience physical and psychological stress due to the caring experience. This study evaluated the benefits of a Psychoeducational Intervention Program (PIP) on caregiver burden in southern Europe.; Methods: A multicentre, prospective, randomised study was conducted. One hundred and fifteen caregivers of patients with clinical diagnosis of AD […]
Donepezil delays progression to AD in MCI subjects with depressive symptoms
Lu, P. H.,
Edland, S. D.,
Teng, E.,
Tingus, K.,
Petersen, R. C.,
Cummings, J. L.
Objective: To determine whether the presence of depression predicts higher rate of progression to Alzheimer disease (AD) in patients with amnestic mild cognitive impairment (aMCI) and whether donepezil treatment beneficially affect this relationship.; Methods: The study sample was composed of 756 participants with aMCI from the 3-year, double-blind, placebo-controlled Alzheimer’s Disease Cooperative Study drug trial […]
Efficacy and safety of memantine in Lewy body dementia
Lewy body dementia (LBD) is a progressive brain disease manifest as dementia and parkinsonism, along with psychotic and autonomic disorders. Although studies in recent years have demonstrated the positive effects of cholinesterase inhibitors in LBD, the search for therapeutic agents with other mechanisms of action remains relevant. An open, controlled, 16-week study was performed with […]
Training in dementia care: a cluster-randomized controlled trial of a training program for nursing home staff in Germany
Kuske, Bettina,
Luck, Tobias,
Hanns, Stephanie,
Matschinger, Herbert,
Angermeyer, Matthias C.,
Behrens, Johann,
Riedel-Heller, Steffi G.
Background: This study examines the effectiveness of a nursing home staff training program designed to improve the interaction between residents with dementia and their caregivers.; Methods: A three-arm cluster-randomized and controlled population of 96 caregivers and 210 residents was used. Caregivers of the intervention group (IG) received a three-month training program in dementia care. Data […]
Effect of aromatherapy on patients with Alzheimer’s disease
Objective: Recently, the importance of non-pharmacological therapies for dementia has come to the fore. In the present study, we examined the curative effects of aromatherapy in dementia in 28 elderly people, 17 of whom had Alzheimer’s disease (AD).; Methods: After a control period of 28 days, aromatherapy was performed over the following 28 days, with […]
Trospium and cognition in patients with late onset Alzheimer disease
Objectives: Cholinesterase inhibitors for the treatment of Alzheimer’s Disease (AD) and antimuscarinic agents for the treatment of urge urinary incontinence (UUI) may reduce the potential effect of each other in the patients with both diseases. Trospium has a relatively low lipophilicity and low CNS penetration, and galantamine, a cholinesterase inhibitors, has also allosterically modulates nicotinic […]
Video programming for individuals with dementia: assessing cognitive congruence
The effect of cognitively congruent video programming on attentional engagement, as measured by the average look duration and the proportion of the video viewed, was examined among long-term care facility residents with Alzheimer’s disease. Over a 2-week period, 24 residents viewed 4 cognitively congruent videos and 1 control video (ie, a recorded episode of a […]