This database contains 32 studies, archived under the term: "Purpose"
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Effect of B vitamins and lowering homocysteine on cognitive impairment in patients with previous stroke or transient ischemic attack: a prespecified secondary analysis of a randomized, placebo-controlled trial and meta-analysis
Hankey, Graeme J.,
Ford, Andrew H.,
Yi, Qilong,
Eikelboom, John W.,
Lees, Kennedy R.,
Chen, Christopher,
Xavier, Denis,
Navarro, Jose C.,
Ranawaka, Udaya K.,
Uddin, Wasim,
Ricci, Stefano,
Gommans, John,
Schmidt, Reinhold,
Almeida, Osvaldo P.,
van Bockxmeer, Frank M.
Background and Purpose: High plasma total homocysteine (tHcy) has been associated with cognitive impairment but lowering tHcy with B-vitamins has produced equivocal results. We aimed to determine whether B-vitamin supplementation would reduce tHcy and the incidence of new cognitive impairment among individuals with stroke or transient ischemic attack≥6 months previously.; Methods: A total of 8164 […]
Study protocol of a randomised controlled group trial of client and care outcomes in the residential dementia care setting
Chenoweth, Lynn,
King, Madeleine,
Luscombe, Georgina,
Forbes, Ian,
Jeon, Yun-Hee,
Parbury, Jane Stein,
Brodaty, Henry,
Fleming, Richard,
Haas, Marion
Purpose: Literature suggests that quality of life (QOL), quality of care (QOC) and Behavioural and Psychological Symptoms of Dementia (BPSD) can be improved by relatively simple and inexpensive person-centred approaches to nursing care practices (PCC) and modifications to physical environment (PCE). Most research on this topic is observational and few randomised controlled trials have included […]
Public-private partnerships improve health outcomes in individuals with early stage Alzheimer’s disease
Purpose: In a collaborative effort between the Missouri Department of Health, Area Agencies on Aging (AAA), Alzheimer Association, and academic researchers, we tested whether early dementia detection and comprehensive care consultations would improve health outcomes in care receivers (CRs) and their family caregivers (FCGs), therefore addressing an important public health concern.; Participants and Methods: A […]
Preserving Identity and Planning for Advance Care (PIPAC): preliminary outcomes from a patient-centered intervention for individuals with mild dementia
Hilgeman, Michelle M.,
Allen, Rebecca S.,
Snow, A. Lynn,
Durkin, Daniel W.,
DeCoster, Jamie,
Burgio, Louis D.
Objectives: The purpose of this pilot study was to conduct limited-efficacy testing of the newly developed Preserving Identity and Planning for Advance Care (PIPAC) intervention on self-reported and proxy-reported emotional and health-related outcomes of individuals in the early stages of dementia.; Method: A two-group comparison design was implemented. Blocked randomization was used to assign individuals […]
Effects of donepezil on cortical activation in mild cognitive impairment: a pilot double-blind placebo-controlled trial using functional MR imaging
Petrella, J. R.,
Prince, S. E.,
Krishnan, S.,
Husn, H.,
Kelley, L.,
Doraiswamy, P. M.
Background and Purpose: Cholinesterase-inhibitor therapy is approved for treatment of Alzheimer disease; however, application in patients with mild cognitive impairment (MCI) is still under active investigation. The purpose of this study was to determine the effect of such therapy on the neural substrates underlying memory processing in subjects with MCI by using functional MR imaging […]
CSF biomarker profile and diagnostic value in vascular dementia
Paraskevas, G. P.,
Kapaki, E.,
Papageorgiou, S. G.,
Kalfakis, N.,
Andreadou, E.,
Zalonis, I.,
Vassilopoulos, D.
Background and Purpose: The differential diagnosis between vascular dementia (VD) and Alzheimer’s disease (AD) or mixed dementia (MD) is not always easy in clinical practice. The purpose of the present study was to evaluate the cerebrospinal fluid (CSF) biomarkers tau protein in its total (tau(T)) or hyperphosphorylated at threonin-181(tau(P-181)) form and beta amyloid peptide 1-42 […]
Voxel-based morphometry in individual patients: a pilot study in early Huntington disease
Mühlau, M.,
Wohlschläger, A. M.,
Gaser, C.,
Valet, M.,
Weindl, A.,
Nunnemann, S.,
Peinemann, A.,
Etgen, T.,
Ilg, R.
Background and Purpose: Voxel-based morphometry (VBM) has proved a powerful method to detect subtle changes of gray matter (GM) at the group level but the role of VBM for the detection of GM changes in single subjects, especially in those with suspected neurodegenerative disorder, remains uncertain. Here, we performed single subject analyses in 22 patients […]
The Tailored Activity Program to reduce behavioral symptoms in individuals with dementia: feasibility, acceptability, and replication potential
Gitlin, Laura N,
Winter, Laraine,
Vause Earland, Tracey,
Adel Herge, E.,
Chernett, Nancy L.,
Piersol, Catherine V.,
Burke, Janice P.
Purpose: The Tailored Activity Program (TAP) is a home-based occupational therapy intervention shown to reduce behavioral symptoms and caregiver burden in a randomized trial. This article describes TAP, its assessments, acceptability, and replication potential.; Design and Methods: TAP involves 8 sessions for a period of 4 months. Interventionists identify preserved capabilities, previous roles, habits, and […]
Effect of music on pain for home-dwelling persons with dementia
The purpose of this study was to investigate the effect of music on pain for home-dwelling persons with dementia. A quasiexperimental design was used. Fifteen subjects listened to their preferred music for 30 minutes before peak agitation time, for 2 days per week, followed by no music for 2 weeks. The process was repeated once. […]