This database contains 203 studies, archived under the term: "Methods"
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Study protocol for a randomized controlled trial of humor therapy in residential care: the Sydney Multisite Intervention of LaughterBosses and ElderClowns (SMILE)
Goodenough, Belinda,
Low, Lee-Fay,
Casey, Anne-Nicole,
Chenoweth, Lynn,
Fleming, Richard,
Spitzer, Peter,
Bell, Jean-Paul,
Brodaty, Henry
Background: Humor therapy is a non-pharmacological intervention with potential to improve mood and quality of life for institutionalized older persons, including those with dementia. The primary aims of the Sydney Multisite Intervention of LaughterBosses and ElderClowns (SMILE) are to examine the effects of humor therapy on residents’ mood, quality of life, social engagement, and agitation.; […]
Factors associated with sustained attention during an activity intervention in persons with dementia
Background/aims: Are the noncognitive factors of self-reported mood and personality related to sustained attention in nursing home residents with dementia during an activity intervention?; Methods: Intervention data from a randomized clinical trial were used to address the aim of this project. Subjects were 128 nursing home residents who were assessed for mood, personality, behavioral indicators […]
Safety and biomarker effects of solanezumab in patients with Alzheimer’s disease
Farlow, Martin,
Arnold, Steven E.,
van Dyck, Christopher H.,
Aisen, Paul S,
Snider, B. Joy,
Porsteinsson, Anton P.,
Friedrich, Stuart,
Dean, Robert A.,
Gonzales, Celedon,
Sethuraman, Gopalan,
Demattos, Ronald B.,
Mohs, Richard,
Paul, Steven M.,
Siemers, Eric R.
Objectives: To assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of 12 weekly infusions of solanezumab, an anti-β-amyloid (Aβ) antibody, in patients with mild-to-moderate Alzheimer’s disease. Cognitive measures were also obtained.; Methods: In this phase 2, randomized, double-blind, placebo-controlled clinical trial, 52 patients with Alzheimer’s disease received placebo or antibody (100 mg every 4 weeks, 100 […]
Physical therapy in Huntington’s disease–toward objective assessments?
Bohlen, S.,
Ekwall, C.,
Hellström, K.,
Vesterlin, H.,
Björnefur, M.,
Wiklund, L.,
Reilmann, R.
Background and Purpose: Physical therapy is recommended for the treatment of Huntington’s disease, but reliable studies investigating its efficacy are almost non-existent. This may in part be due to the lack of suitable outcome measures. Therefore, we investigated the applicability of novel quantitative and objective assessments of motor dysfunction in the evaluation of physical therapy […]
Effectiveness of family meetings for family caregivers on delaying time to nursing home placement of dementia patients: a randomized trial
Joling, Karlijn J,
van Marwijk, Harm W.J.,
van der Horst, Henriëtte E,
Scheltens, Philip,
van de Ven, Peter M.,
Appels, Bregje A.,
van Hout, Hein P.J.
Background: Interventions relieving the burden of caregiving may postpone or prevent patient institutionalization. The objective of this study was to determine whether a family meetings intervention was superior to usual care in postponing nursing home placement of patients with dementia.; Methods: A randomized multicenter trial was conducted among 192 patients with a clinical diagnosis of […]
Improvement in delusions and hallucinations in patients with dementia with Lewy bodies upon administration of yokukansan, a traditional Japanese medicine
Iwasaki, Koh,
Kosaka, Kenji,
Mori, Hideo,
Okitsu, Reina,
Furukawa, Katsutoshi,
Manabe, Yuta,
Yoshita, Mitsuhiro,
Kanamori, Aya,
Ito, Nobuo,
Wada, Kenji,
Kitayama, Michio,
Horiguchi, Jun,
Yamaguchi, Shuhei,
Takayama, Shin,
Fukuhara, Ryuji,
Ouma, Shinji,
Nakano, Seigo,
Hashimoto, Mamoru,
Kinoshita, Toru
Background: This multicentre open-label trial examined the efficacy and safety of the traditional Japanese medicine, or Kampo medicine, yokukansan (YKS), for behavioural and psychological symptoms of dementia (BPSD) in patients with dementia with Lewy bodies.; Methods: Sixty-three dementia with Lewy bodies patients with probable BPSD (M:W, 30:33; mean age, 78.2±5.8 years) were enrolled and treated […]
Donepezil for dementia with Lewy bodies: a randomized, placebo-controlled trial
Objective: Because cholinergic deficits are prominent in dementia with Lewy bodies (DLB), we investigated the effects of a cholinesterase inhibitor, donepezil, in such patients in a randomized, double-blind, placebo-controlled exploratory phase 2 trial.; Methods: One-hundred forty patients with DLB, recruited from 48 specialty centers in Japan, were randomly assigned to receive placebo or 3, 5, […]
Leisure activities alleviate depressive symptoms in nursing home residents with very mild or mild dementia
Objectives: : To examine whether leisure activities can alleviate depressive symptoms among nursing home residents with very mild to mild dementia.; Methods: : A cluster-randomized open-label controlled design. Thirty-six residents with at least moderate depressive symptoms were randomized by home into three conditions-mahjong (a.k.a. mah-jongg), tai chi, and handicrafts (placebo). Activities were conducted three times […]