Louis, Elan D., Benito-León, Julián, Bermejo-Pareja, Félix

Background: Recent interest in antihypertensive agents, especially calcium channel blockers, has been sparked by the notion that these medications may be neuroprotective. A modest literature, with mixed results, has examined whether these medications might lower the odds or risk of Parkinson’s disease (PD) or dementia. There are no data for essential tremor (ET).; Objective: To […]

Kiely, Dan K., Givens, Jane L., Shaffer, Michele L., Teno, Joan M., Mitchell, Susan L.

Objectives: To identify characteristics of nursing home (NH) residents with advanced dementia and their healthcare proxies (HCPs) associated with hospice referral and to examine the association between hospice use and the treatment of pain and dyspnea and unmet needs during the last 7 days of life.; Design: Prospective cohort study.; Setting: Twenty-two Boston-area NHs.; Participants: […]

Barnes, Lisa L., Mendes de Leon, Carlos F., Bienias, Julia L., Wilson, Robert S., Everson-Rose, Susan A., Evans, Denis A.

Objective: To test whether the level of hostility predicted the rate of cognitive decline in a community of older blacks and whites and whether the association varied as a function of race.; Methods: Over 4800 persons from a defined community in Chicago completed up to three structured interviews at approximately 3 year intervals over a […]

Albani, Diego, Martinelli Boneschi, Filippo, Biella, Gloria, Giacalone, Giacomo, Lupoli, Sara, Clerici, Francesca, Benussi, Luisa, Ghidoni, Roberta, Galimberti, Daniela, Squitti, Rosanna, Mariani, Stefania, Confaloni, Annamaria, Bruno, Giuseppe, Mariani, Claudio, Scarpini, Elio, Binetti, Giuliano, Magnani, Giuseppe, Franceschi, Massimo, Forloni, Gianluigi

Alzheimer’s disease (AD) is a neurodegenerative disorder often treated with donepezil, an acetylcholinesterase inhibitor. Response to donepezil is variable, probably based on patients’ genetic background in donepezil metabolizing enzymes, including cytochrome 2D6 (CYP2D6). We evaluated the association between clinical response to donepezil and a common variant (rs1080985) of CYP2D6, previously reported to be associated with […]