Thiyagesh, Subha N., Farrow, Tom F. D., Parks, Randolph W., Accosta-Mesa, Hector, Hunter, Michael D., Young, Claire, Wilkinson, lain D., Woodruff, Peter W. R.

Background/Aims: Visuospatial impairments are known to occur in Alzheimer’s disease (AD). We hypothesised that functional magnetic resonance imaging (fMRI) response in task-related brain regions would be impaired in patients with AD during the task and that treatment with acetyl cholinesterase inhibitors would enhance activations in brain regions concerned with this visual perceptual processing. Method: Ten […]

Wilkinson, David, Fox, Nick C., Barkhof, Frederik, Phul, Ravinder, Lemming, Ole, Scheltens, Philip

The primary objective of this study was to evaluate the rate of total brain atrophy (TBA) with serial magnetic resonance imaging (MRI), using the Brain Boundary Shift Integral (BBSI), in patients with probable Alzheimer’s disease (AD) over the course of 52 weeks of treatment with memantine or placebo. This was a multi-national, randomized, double-blind, placebo-controlled, […]

Rothi, Leslie J. Gonzalez, Fuller, Renee, Leon, Susan A., Kendall, Diane, Moore, Anna, Wu, Samuel S., Crosson, Bruce, Heilman, Kenneth M., Nadeau, Stephen E.

Six individuals with probable Alzheimer’s disease (AD) participated in a phase 1 study employing a repeated measures, parallel baseline design testing the hypothesis that error-free experience during word production practice combined with an acetyl cholinesterase inhibitor would improve confrontation naming ability. While acetyl cholinesterase inhibitors are safe and delay cognition decline associated with AD, improvement […]