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Additional use of Aβ₄₂/Aβ₄₀ ratio with cerebrospinal fluid biomarkers P-tau and Aβ₄₂ increases the level of evidence of Alzheimer’s disease pathophysiological process in routine practice
Sauvée, Mathilde,
DidierLaurent, Guerric,
Latarche, Clotilde,
Escanyé, Marie-Christine,
Olivier, Jean-Luc,
Malaplate-Armand, Catherine
...to 87%, without changing the conclusion when usual biomarkers (Aβ42 and P-tau) were concordant.; Conclusion: Our results support the use of the Aβ42/Aβ40 ratio in addition to the usual CSF...
Improvements in gait characteristics after intensive resistance and functional training in people with dementia: a randomised controlled trial
Schwenk, Michael,
Zieschang, Tania,
Englert, Stefan,
Grewal, Gurtej,
Najafi, Bijan,
Hauer, Klaus
...(P < 0.001), cadence (P = 0.002), stride length (P = 0.008), stride time (P = 0.001), and double support (P = 0.001) in the IG compared to the CG....
Statins as neuroprotectants: a comparative in vitro study of lipophilicity, blood-brain-barrier penetration, lowering of brain cholesterol, and decrease of neuron cell death
Sierra, Saleta,
Ramos, Maria C.,
Molina, Pilar,
Esteo, Cynthia,
Vázquez, Jose Antonio,
Burgos, Javier S.
...There is growing evidence to support the hypothesis that statins may act as neuroprotectants in several neuropathological conditions, including Alzheimer’s disease. The mechanisms for neuroprotection are only partially understood,...
The peaceful mind program: a pilot test of a cognitive-behavioral therapy-based intervention for anxious patients with dementia
Stanley, Melinda A.,
Calleo, Jessica,
Bush, Amber L.,
Wilson, Nancy,
Snow, A. Lynn,
Kraus-Schuman, Cynthia,
Paukert, Amber L.,
Petersen, Nancy J.,
Brenes, Gretchen A.,
Schulz, Paul E.,
Williams, Susan P.,
Kunik, Mark E.
...Although significant positive effects were not noted in other outcomes or at 6-month follow-up, the pilot nature of the trial prohibits conclusions about efficacy.; Conclusions: Results support that Peaceful Mind...
The Peaceful Mind program: A pilot test of a cognitive–behavioral therapy–based intervention for anxious patients with Dementia
Stanley, Melinda A.,
Calleo, Jessica,
Bush, Amber L.,
Wilson, Nancy,
Snow, A. Lynn,
Kraus-Schuman, Cynthia,
Paukert, Amber L.,
Petersen, Nancy J.,
Brenes, Gretchen A.,
Schulz, Paul E.,
Williams, Susan P.,
Kunik, Mark E.
...Although significant positive effects were not noted in other outcomes or at 6-month follow-up, the pilot nature of the trial prohibits conclusions about efficacy. Conclusions: Results support that Peaceful Mind...
Infection hospitalization increases risk of dementia in the elderly
Tate, Judith A.,
Snitz, Beth E.,
Alvarez, Karina A.,
Nahin, Richard L.,
Weissfeld, Lisa A.,
Lopez, Oscar,
Angus, Derek C.,
Shah, Faraaz,
Ives, Diane G.,
Fitzpatrick, Annette L.,
Williamson, Jeffrey D.,
Arnold, Alice M.,
DeKosky, Steven T.,
Yende, Sachin
...cases necessitated ICU admission, mechanical ventilation, or vasopressor support. Dementia was adjudicated based on neuropsychological evaluation, neurological examination, and MRI. Two hundred twenty-one participants (7.2%) incurred at least one hospitalization...
Staff training in assisted living: evaluating treatment fidelity
Teri, Linda,
McKenzie, Glenise L.,
Pike, Kenneth C.,
Farran, Carol J.,
Beck, Cornelia,
Paun, Olimpia,
LaFazia, David
...consequences (an essential component of training); understanding basics of dementia care; and applying STAR techniques.; Conclusions: Results support that STAR is ready to be translated and disseminated into practice. Because...
Cognitive rehabilitation changes memory-related brain activity in people with Alzheimer disease
van Paasschen, J.,
Clare, L.,
Yuen, K. S. L.,
Woods, R. T.,
Evans, S. J.,
Parkinson, C. H.,
Rugg, M. D.,
Linden, D. E. J.
...Background: People with Alzheimer disease (AD) are capable of new learning when cognitive support is provided, suggesting that there is plasticity even in a degenerating brain. However, it is...