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PRECREST: a phase II prevention and biomarker trial of creatine in at-risk Huntington disease
Rosas, H. D.,
Doros, G.,
Gevorkian, S.,
Malarick, K.,
Reuter, M.,
Coutu, J.-P.,
Triggs, T. D.,
Wilkens, P. J.,
Matson, W.,
Salat, D. H.,
Hersch, S. M.
...and blood markers.; Methods: Sixty-four eligible consenting participants were randomly allocated (1:1) to 15 g twice daily of creatine monohydrate or placebo for a 6-month double-blind phase followed by a...
Safety and efficacy of methylphenidate for apathy in Alzheimer’s disease: A randomized, placebo-controlled trial
Rosenberg, Paul B.,
Lanctôt, Krista L.,
Drye, Lea T.,
Herrmann, Nathan,
Scherer, Roberta W.,
Bachman, David L.,
Mintzer, Jacobo E.
...double-blind, placebo-controlled multicenter trial enrolling Alzheimer’s disease participants (NINCDS-ADRDA criteria) with apathy assigned to methylphenidate 20 mg daily or placebo, conducted from June 2010 to December 2011. Primary outcomes were...
Cognitive dysfunction in HIV patients despite long-standing suppression of viremia
Simioni, Samanta,
Cavassini, Matthias,
Annoni, Jean-Marie,
Rimbault Abraham, Aline,
Bourquin, Isabelle,
Schiffer, Véronique,
Calmy, Alexandra,
Chave, Jean-Philippe,
Giacobini, Ezio,
Hirschel, Bernard,
Du Pasquier, Renaud A.
...daily life (asymptomatic neurocognitive impairment) is the most frequent subtype observed. In this population, the HIV dementia scale with a cutoff of 14 points or less seems to provide a...
Donepezil treatment stabilizes functional connectivity during resting state and brain activity during memory encoding in Alzheimer’s disease
Solé-Padullés, Cristina,
Bartrés-Faz, David,
Lladó, Albert,
Bosch, Beatriz,
Peña-Gómez, Cleofé,
Castellví, Magdalena,
Rami, Lorena,
Bargalló, Nuria,
Sánchez-Valle, Raquel,
Molinuevo, José Luis
...treatment (n = 8) or to control group (n = 7); the former receiving daily treatment of donepezil during 3 months. At baseline and follow-up, both groups underwent resting-state as...
Effects of dementia-care mapping on residents and staff of care homes: a pragmatic cluster-randomised controlled trial
van de Ven, Geertje,
Draskovic, Irena,
Adang, Eddy M. M.,
Donders, Rogier,
Zuidema, Sytse U.,
Koopmans, Raymond T. C. M.,
Vernooij-Dassen, Myrra J. F. J.
...DCM intervention. In order to be able to inform daily practice, we studied DCM effectiveness in a pragmatic cRCT involving a wide range of care homes with trained nursing staff...
The implementation of integrated emotion-oriented care: did it actually change the attitude, skills and time spent of trained caregivers?
van der Kooij, C.,
Droes, R.,
de Lange, J.,
Ettema, T.,
Cools, H.,
van Tilburg, W.
...nursing home wards. The main question was whether the trained caregivers actually applied the knowledge and techniques of IEOC during their daily work.; Methods: The study was conducted within the...
Efficacy of a cognitive training programme for mild cognitive impairment: Results of a randomised controlled study
Jean, Léonie,
Simard, Martine,
Wiederkehr, Sandra,
Bergeron, Marie-Ève,
Turgeon, Yves,
Hudon, Carol,
Tremblay, Isabelle,
van Reekum, Robert
...and in the frequency with which the participants used strategies to support memory functions in daily life. The absence of difference between groups on all variables might be partly explained...