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Yogic meditation reverses NF-κB and IRF-related transcriptome dynamics in leukocytes of family dementia caregivers in a randomized controlled trial
Black, David S.,
Cole, Steve W.,
Irwin, Michael R.,
Breen, Elizabeth,
St. Cyr, Natalie M.,
Nazarian, Nora,
Khalsa, Dharma S.,
Lavretsky, Helen
Background: Although yoga and meditation have been used for stress reduction with reported improvement in inflammation, little is known about the biological mechanisms mediating such effects. The present study examined if a yogic meditation might alter the activity of inflammatory and antiviral transcription control pathways that shape immune cell gene expression. Methods: Forty-five family dementia […]
Olive oil and cognition: results from the three-city study
Berr, Claudine,
Portet, Florence,
Carrière, Isabelle,
Akbaraly, Tasnime N.,
Feart, Catherine,
Gourlet, Véronique,
Combe, Nicole,
Barberger-Gateau, Pascale,
Ritchie, Karen
Background: Olive oil is a major component of the Mediterranean diet suggested to be beneficial to counteract Alzheimer’s disease.; Aim Of the Study: Our objective was to examine the association between olive oil use, cognitive deficit and cognitive decline in a large elderly population.; Methods: We followed 6,947 subjects with a brief baseline food frequency […]
Risk of incident dementia in drug-untreated arterial hypertension: a population-based study
Bermejo-Pareja, Félix,
Benito-León, Julián,
Louis, Elan D.,
Trincado, Rocío,
Carro, Eva,
Villarejo, Alberto,
de la Cámara, Agustín Gómez
Arterial hypertension in midlife may increase the risk of late-life dementia. Notably, there is conflicting data as to whether hypertension in the elderly (age 65 years and older) is a risk factor for dementia and Alzheimer’s disease (AD). We determined whether drug-untreated hypertension was associated with a higher risk of incident dementia and AD. In […]
Predicting decline in mild cognitive impairment: A prospective cognitive study
Objective: The primary aim of this study was to identify cognitive tests that differentiate between persons with mild cognitive impairment (MCI) who later develop cognitive decline and those who remain stable. Method: This study used a prospective longitudinal design. One hundred twenty-two older adults with single-domain or multiple-domain amnestic MCI were recruited from memory clinics. […]
Results of the citalopram to enhance cognition in Huntington disease trial
Beglinger, Leigh J.,
Adams, William H.,
Langbehn, Douglas,
Fiedorowicz, Jess G.,
Jorge, Ricardo,
Biglan, Kevin,
Caviness, John,
Olson, Blair,
Robinson, Robert G.,
Kieburtz, Karl,
Paulsen, Jane S.
Background: The objective of this study was to evaluate citalopram for executive functioning in Huntington’s disease (HD).; Methods: The study was randomized, double-blind, and placebo-controlled. Thirty-three adults with HD, cognitive complaints, and no depression (Hamilton Depression [HAM-D] rating scale ≤ 12) were administered citalopram 20 mg or placebo (7 visits, 20 weeks), with practice and […]
A cluster-randomised trial of staff education to improve the quality of life of people with dementia living in residential care: the DIRECT study
Beer, Christopher,
Horner, Barbara,
Flicker, Leon,
Scherer, Samuel,
Lautenschlager, Nicola T.,
Bretland, Nick,
Flett, Penelope,
Schaper, Frank,
Almeida, Osvaldo P.
Background: The Dementia In Residential care: EduCation intervention Trial (DIRECT) was conducted to determine if delivery of education designed to meet the perceived need of GPs and care staff improves the quality of life of participants with dementia living in residential care.; Methodology/principal Findings: This cluster-randomised controlled trial was conducted in 39 residential aged care […]