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This database contains 1433 studies, archived under the term: ""

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Combating depression in Huntington’s disease: effective antidepressive treatment with venlafaxine XR
Patients with Huntington’s disease (HD) often suffer from psychiatric symptoms including affective disorder, psychosis, irritability, and apathy, which may be present in all stages of the disease. However–despite the obvious likelihood that these symptoms may be reduced by antidepressive treatments–to date, the effectiveness of such treatments in HD has only ever been examined in case […]

Are optimal levels of testosterone associated with better cognitive function in healthy older women and men?
Background: Sex steroids can positively affect the brain and from this it would follow that high levels of sex steroids could be associated with better cognitive function in older men and women.; Methods: This Healthy Ageing Study sample comprised of 521 older participants (51% women) without dementia at baseline, with an age range from 64 […]

Influence of regular exercise on subjective sense of burden and physical symptoms in community-dwelling caregivers of dementia patients: a randomized controlled trial
With an aim to improve quality of life in caregivers of dementia patients, we examined the effect of regular exercise on caregivers’ sense of burden and their physical symptoms. Participants were 31 elderly caregivers living with older patients diagnosed with Alzheimer’s-type dementia. They were randomly assigned to either the intervention group, who were prescribed regular […]

Unintended effects of statins in men and women in England and Wales: population based cohort study using the QResearch database
Objective: To quantify the unintended effects of statins according to type, dose, and duration of use.; Design: Prospective open cohort study using routinely collected data.; Setting: 368 general practices in England and Wales supplying data to the QResearch database.; Participants: 2 004 692 patients aged 30-84 years of whom 225 922 (10.7%) were new users […]

Personality as a moderator of cognitive stimulation in older adults at high risk for cognitive decline
This exploratory study examined the moderating effects of personality traits on cognitive function following a cognitively stimulating individualized activity intervention delivered to individuals at high risk for cognitive decline: those with delirium superimposed on dementia. Data were taken from an ongoing randomized clinical trial with the addition of a personality measure. The results for 71 […]

Ankle blood pressure and dementia: a prospective follow-up study
Background and Objective: Ankle blood pressure may be a useful indicator of arterial stiffness. The main aim of the present study was to examine the relationship of ankle blood pressure measured in midlife with the risk of dementia with advancing age. A secondary aim was to examine the relationship of physical exercise capacity in midlife […]

Navigation for people with mild dementia
Community dwelling is a problem for people with dementia. Can GPS route navigation support on a mobile device provide a solution? In a small scale exploratory research with this target group we studied the effects of two different types of audio instructions and assessed the pedestrian safety while operating the device. Methodological issues that limited […]

A randomized, double-blind, placebo-controlled trial of memantine in a behaviorally enriched sample of patients with moderate-to-severe Alzheimer’s disease
Background: Agitation and aggression in Alzheimer’s disease (AD) are amongst the most serious of neuropsychiatric symptoms, and contribute to poor outcomes and worse quality of life. Previous studies have suggested a benefit for memantine on agitation and aggression, but none have examined its efficacy in community-dwelling patients with significant agitation and aggression at baseline, utilizing […]

Persistence with cholinesterase inhibitor therapy for dementia: an observational administrative health database study
Objective: To determine if choice of drug and ease of administration affect persistence of therapy with cholinesterase inhibitors (ChEIs) for treatment of dementia.; Methods: An observational administrative health database study was conducted in 5622 patients aged >or=65 years who received a new prescription for donepezil (DON), rivastigmine (RIV) or galantamine (GAL) from February to May […]

Time until incident dementia among Medicare beneficiaries using centrally acting or non-centrally acting ACE inhibitors
Background: Centrally active (CA) angiotensin-converting enzyme inhibitors (ACEIs) are able to cross the blood–brain barrier. Small observational studies and mouse models suggest that use of CA versus non-CA ACEIs is associated with a reduced incidence of Alzheimer’s disease and related dementias (ADRD).; Objective: The aim of this research was to assess the effect of CA […]

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