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Demonstration of safety in Alzheimer’s patients for intervention with an anti-hypertensive drug Nilvadipine: results from a 6-week open label study
Kennelly, S. P.,
Abdullah, L.,
Paris, D.,
Parish, J.,
Mathura, V.,
Mullan, M.,
Crawford, F.,
Lawlor, B. A.,
Kenny, R. A.
Background: Nilvadipine may lower rates of conversion from mild-cognitive impairment to Alzheimer’s disease (AD), in hypertensive patients. However, it remains to be determined whether treatment with nilvadipine is...
A home‐based training program improves Taiwanese family caregivers’ quality of life and decreases their risk for depression: A randomized controlled trial
Kuo, Li-Min,
Huang, Huei-Ling,
Huang, Hsiu-Li,
Liang, Jersey,
Chiu, Yi-Chen,
Chen, Sien-Tsong,
Kwok, Yam-Ting,
Hsu, Wen-Chuin,
Shyu, Yea-Ing L.
Objectives: Little is known about the longitudinal effects of training programs on family caregivers’ health-related quality of life (HRQoL) and depressive symptoms over time. Therefore, the purpose of...
A pilot study of yogic meditation for family dementia caregivers with depressive symptoms: effects on mental health, cognition, and telomerase activity
Lavretsky, H.,
Epel, E.S.,
Siddarth, P.,
Nazarian, N.,
Cyr, N. St.,
Khalsa, D.S.,
Lin, J.,
Blackburn, E.,
Irwin, M.R.
Background: This study examined the effects of brief daily yogic meditation on mental health, cognitive functioning, and immune cell telomerase activity in family dementia caregivers with mild depressive...
Effect of a high-intensity functional exercise program on functional balance: preplanned subgroup analyses of a randomized controlled trial in residential care facilities
Littbrand, Håkan,
Carlsson, Maine,
Lundin-Olsson, Lillemor,
Lindelöf, Nina,
Håglin, Lena,
Gustafson, Yngve,
Rosendahl, Erik
...of depressive symptoms (P=.85, .49, respectively).; Conclusion: Older age, female sex, depression, mild to moderate dementia syndrome, malnutrition, and severe physical impairment do not seem to have a negative effect...
Optimal blood pressure for cognitive function: findings from an elderly African-American cohort study
Liu, Hai,
Gao, Sujuan,
Hall, Kathleen S.,
Unverzagt, Frederick W.,
Lane, Kathleen A.,
Callahan, Christopher M.,
Hendrie, Hugh C.
Objectives: To report the results from a prospective cohort study on the association between blood pressure (BP) and cognitive function in elderly African Americans.; Design: Prospective cohort study...
A phase II trial of tideglusib in Alzheimer’s disease
Lovestone, Simon,
Boadab, Mercè,
Dubois, Bruno,
Hüll, Michael,
Rinne, Juha O.,
Huppertz, Hans-Jürgen,
Calero, Miguel,
Andrés, María V.,
Gómez-Carrillo, Belén,
Leon, Teresa,
del Seri, Teodoro
Background: The ARGO study was a phase II, double-blind, placebo controlled, four parallel arm trial of tideglusib in Alzheimer’s disease (AD). Objective: To prove the clinical efficacy of...
Virgin olive oil supplementation and long-term cognition: the PREDIMED-NAVARRA randomized, trial
Martínez-Lapiscina, Elena H,
Clavero, P.,
Toledo, E.,
San Julian, B.,
Sanchez-Tainta, A.,
Corella, D.,
Lamuela-Raventos, R. M.,
Martinez, J. A.,
Martinez-Gonzalez, M. Á.
...After adjustment for sex, age, education, apolipoprotein E genotype, family history of cognitive impairment/dementia, smoking, physical activity, body mass index, hypertension, dyslipidaemia, diabetes, alcohol and total energy intake, this group...
Donepezil improves gait performance in older adults with mild Alzheimer’s disease: A phase II clinical trial
Montero-Odasso, Manuel,
Muir-Hunter, Susan W.,
Oteng-Amoako, Afua,
Gopaul, Karen,
Islam, Anam,
Borrie, Michael,
Wells, Jennie,
Speechley, Mark
Background: Gait deficits are prevalent in people with dementia and increase their fall risk and future disability. Few treatments exist for gait impairment in Alzheimer’s disease (AD) but...