This database contains 31 studies, archived under the term: "with"
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Effects of n-3 fatty acids, EPA v. DHA, on depressive symptoms, quality of life, memory and executive function in older adults with mild cognitive impairment: a 6-month randomised controlled trial
Sinn, Natalie,
Milte, Catherine M.,
Street, Steven J.,
Buckley, Jonathan D.,
Coates, Alison M.,
Petkov, John,
Howe, Peter R.C.
Depressive symptoms may increase the risk of progressing from mild cognitive impairment (MCI) to dementia. Consumption of n-3 PUFA may alleviate both cognitive decline and depression. The aim of the present study was to investigate the benefits of supplementing a diet with n-3 PUFA, DHA and EPA, for depressive symptoms, quality of life (QOL) and […]
Memantine for dementia in adults older than 40 years with Down’s syndrome (MEADOWS): a randomised, double-blind, placebo-controlled trial
Hanney, Marisa,
Prasher, Vee,
Williams, Nicola,
Jones, Emma L.,
Aarsland, Dag,
Corbett, Anne,
Lawrence, Dale,
Yu, Ly-Mee,
Tyrer, Stephen,
Francis, Paul T.,
Johnson, Tony,
Bullock, Roger,
Ballard, Clive
Background: Prevalence of Alzheimer’s disease in people with Down’s syndrome is very high, and many such individuals who are older than 40 years have pathological changes characteristic of Alzheimer’s disease. Evidence to support treatment with Alzheimer’s drugs is inadequate, although memantine is beneficial in transgenic mice. We aimed to assess safety and efficacy of memantine […]
REMCARE: reminiscence groups for people with dementia and their family caregivers – effectiveness and cost-effectiveness pragmatic multicentre randomised trial
Woods, R. T.,
Bruce, E.,
Edwards, R. T.,
Elvish, R.,
Hoare, Z.,
Hounsome, B.,
Keady, J.,
Moniz-Cook, E. D.,
Orgeta, V.,
Orrell, M.,
Rees, J.,
Russell, I. T.
Objectives: The aim of the REMiniscence groups for people with dementia and their family CAREgivers (REMCARE) study was to assess the effectiveness and cost-effectiveness of joint reminiscence groups for people with dementia and their family caregivers as compared with usual care.; Design: A multicentre, pragmatic randomised controlled trial with two parallel arms – an intervention […]
Public-private partnerships improve health outcomes in individuals with early stage Alzheimer’s disease
Purpose: In a collaborative effort between the Missouri Department of Health, Area Agencies on Aging (AAA), Alzheimer Association, and academic researchers, we tested whether early dementia detection and comprehensive care consultations would improve health outcomes in care receivers (CRs) and their family caregivers (FCGs), therefore addressing an important public health concern.; Participants and Methods: A […]
Effects of scalp acupuncture combined with auricular point sticking on cognitive behavior ability in patients with vascular dementia
Li, Si-Kang,
Ding, Ding-Ming,
Zhang, Zheng-Long,
Ma, Lan,
Huang, Hai-Yan,
Wu, Xiao-Hong
Objective: To compare the therapeutic differences among scalp acupuncture combined with auricular point sticking, body acupuncture and western medication for treatment of vascular dementia (VD).; Methods: Ninety cases were randomly divided into a combined therapy group (31 cases), a body acupuncture group (29 cases) and a western medication group (30 cases). The combined therapy group […]
Memantine effects on verbal memory in fragile X-associated tremor/ataxia syndrome (FXTAS): A double-blind brain potential study
Yang, Jin-Chen,
Niu, Yu-Qiong,
Simon, Christa,
Seritan, Andreea L,
Chen, Lawrence,
Schneider, Andrea,
Moghaddam, Shayan T,
Hagerman, Paul J,
Hagerman, Randi J,
Olichney, John M
Older FMR1 premutation carriers may develop fragile X-associated tremor/ataxia syndrome (FXTAS), a neurodegenerative disorder manifesting cognitive deficits that often subsequently progress to dementia. To date, there is no specific treatment available for FXTAS. Studies have demonstrated the premutation-associated overactivation of glutamatergic receptors in neurons. Memantine, a NMDA receptor antagonist approved for treatment of Alzheimer’s disease, […]
Cognitive function and brain structure in persons with type 2 diabetes mellitus after intensive lowering of blood pressure and lipid levels: a randomized clinical trial
Williamson, Jeff D.,
Launer, Lenore J.,
Bryan, R. Nick,
Coker, Laura H.,
Lazar, Ronald M.,
Gerstein, Hertzel C.,
Murray, Anne M.,
Sullivan, Mark D.,
Horowitz, Karen R.,
Ding, Jingzhong,
Marcovina, Santica,
Lovato, Laura,
Lovato, James,
Margolis, Karen L.,
Davatzikos, Christos,
Barzilay, Joshua,
Ginsberg, Henry N.,
Linz, Peter E.,
Miller, Michael E.
Importance: Persons with type 2 diabetes mellitus (T2DM) are at increased risk for decline in cognitive function, reduced brain volume, and increased white matter lesions in the brain. Poor control of blood pressure (BP) and lipid levels are risk factors for T2DM-related cognitive decline, but the effect of intensive treatment on brain function and structure […]
A comparison of neurocognitive impairment in younger and older adults with major depression
Thomas, A. J.,
Gallagher, P.,
Robinson, L. J.,
Porter, R. J.,
Young, A. H.,
Ferrier, I. N.,
O'Brien, J. T.
Background: Neurocognitive impairment is a well-recognized feature of depression that has been reported in younger and older adults. Similar deficits occur with ageing and it is unclear whether the greater deficits in late-life depression are an ageing-related phenomenon or due to a difference in the nature of late-life depression itself. We hypothesized that ageing alone […]