This database contains 370 studies, archived under the term: "treatment outcome"
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Sustainability of motor training effects in older people with dementia
Evidence for sustainability of motor training effects in people with dementia is lacking. To examine whether the substantial improvements in motor performance achieved through a three-month specialized, standardized motor training were sustained, the participants of the randomized controlled trial were re-evaluated nine months after training had ceased. As part of a comprehensive study, participants with […]
Improvement in memory with plasticity-based adaptive cognitive training: results of the 3-month follow-up
Zelinski, Elizabeth M.,
Spina, Laila M.,
Yaffe, Kristine,
Ruff, Ronald,
Kennison, Robert F.,
Mahncke, Henry W.,
Smith, Glenn E.
Objectives: To investigate maintenance of training effects of a novel brain plasticity-based computerized cognitive training program in older adults after a 3-month no-contact period.; Design: Multisite, randomized, controlled, double-blind trial with two treatment groups.; Setting: Communities in northern and southern California and Minnesota.; Participants: Four hundred eighty-seven community-dwelling adults aged 65 and older without diagnosis […]
Concentration of donepezil to the cognitive response in Alzheimer disease
Yang, Yuan-Han,
Chen, Chun-Hung,
Chou, Mei-Chuan,
Li, Chien-Hsun,
Liu, Ching-Kuan,
Chen, Su-Hwei
Background: Donepezil has been approved, and higher dosages are recommended for the treatment of Alzheimer disease (AD). However, a few studies have reported different cognitive responses in patients with AD treated with donepezil without measuring the concentration.; Methods: We evaluated the relationships between the therapeutic responses and plasma concentrations of donepezil in various cognitive domains […]
Effects of cognitive stimulation therapy Japanese version (CST-J) for people with dementia: a single-blind, controlled clinical trial
Yamanaka, Katsuo,
Kawano, Yoshiyuki,
Noguchi, Dai,
Nakaaki, Shutaro,
Watanabe, Norio,
Amano, Takashi,
Spector, Aimee
Objectives: Cognitive stimulation therapy (CST) has shown to have significant benefits in improving the cognitive function and quality of life (QOL) in people with mild-to-moderate dementia in a UK randomized controlled trial (RCT). We developed and examined the Japanese version of group CST (CST-J) in a single-blind, controlled clinical trial.; Method: CST-J consisting of 14 […]
Effect of rhythmic auditory cueing on gait in people with Alzheimer disease
Objective: To determine whether rhythmic music and metronome cues alter spatiotemporal gait measures and gait variability in people with Alzheimer disease (AD).; Design: A repeated-measures study requiring participants to walk under different cueing conditions.; Setting: University movement laboratory.; Participants: Of the people (N=46) who met study criteria (a diagnosis of probable AD and ability to […]
The influence of Nintendo-Wii® bowling upon residents of retirement homes
The few studies dealing with the positive effects of health and well-being of older people are only one-sided. The aim of the study therefore was to analyze the effects of Nintendo-Wii® bowling on daily function, state of dementia, quality of life, cognition and motor skills in retirement home inhabitants. The study was performed with 27 […]
Cognitive function and brain structure in persons with type 2 diabetes mellitus after intensive lowering of blood pressure and lipid levels: a randomized clinical trial
Williamson, Jeff D.,
Launer, Lenore J.,
Bryan, R. Nick,
Coker, Laura H.,
Lazar, Ronald M.,
Gerstein, Hertzel C.,
Murray, Anne M.,
Sullivan, Mark D.,
Horowitz, Karen R.,
Ding, Jingzhong,
Marcovina, Santica,
Lovato, Laura,
Lovato, James,
Margolis, Karen L.,
Davatzikos, Christos,
Barzilay, Joshua,
Ginsberg, Henry N.,
Linz, Peter E.,
Miller, Michael E.
Importance: Persons with type 2 diabetes mellitus (T2DM) are at increased risk for decline in cognitive function, reduced brain volume, and increased white matter lesions in the brain. Poor control of blood pressure (BP) and lipid levels are risk factors for T2DM-related cognitive decline, but the effect of intensive treatment on brain function and structure […]