This database contains 370 studies, archived under the term: "treatment outcome"
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Clinical rehabilitative effect of memantine on cognitive and motor disorders in patients with Parkinson’s disease
Li, Wei,
Zhao, Jian-Hua,
Sun, Sheng-Gang,
Zhang, Jie-Wen,
Suo, Ai-Qin,
Ma, Ming-Ming
Objective: To study the effects of memantine on cognitive and motor impairment in patients with Parkinson’s disease (PD).; Methods: A total of 55 PD patients complicated by varying degrees of cognitive impairment were randomly divided into two groups. The patients of experimental group (n = 28) received memantine (20 mg/d) while those in the control […]
Influence of acupuncture on isoprostane in patients with Alzheimer’s disease
Zhu, Hong,
Dong, Ke-Li,
Wu, Yue,
Zhang, Ting,
Li, Ruo-meng,
Dai, Si-si,
Wang, Hui-ling
Objective: To explore the clinical therapeutic effect of acupuncture on Alzheimer’s disease (AD) and its mechanism.; Methods: Twenty patients with Alzheimer’s disease were treated by acupuncture with reinforcing kidney and activating blood method for 12 weeks and Baihui (GV 20), Shenshu (BL 23), Xuehai (SP 10) and Geshu (BL 17) were selected. The clinical therapeutic […]
Effect of Active Music Therapy and Individualized Listening to Music on Dementia: A Multicenter Randomized Controlled Trial
Raglio, A.,
Bellandi, D.,
Baiardi, P.,
Gianotti, M.,
Ubezio, M.C.,
Zanacchi, E.,
Granieri, E.,
Imbriani, M.,
Stramba-Badiale, M.
OBJECTIVES: To assess the effects of active music therapy (MT) and individualized listening to music (LtM) on behavioral and psychological symptoms of dementia (BPSDs) in persons with dementia (PWDs). DESIGN: Randomized controlled trial. SETTING: Nine Italian institutions. PARTICIPANTS: Persons with moderate to severe dementia and BPSDs (N = 120) were randomized to one of three […]
Methodological issues in a cluster-randomized trial to prevent dementia by intensive vascular care
Objectives: Description of methodological issues in a trial designed to evaluate if a multi-component intervention aimed at vascular risk factors can prevent dementia.; Design, Setting and Participants: Multi-center, open, cluster-randomized controlled clinical trial (preDIVA) including 3535 non-demented subjects aged 70-78, executed in primary practice and coordinated from one academic hospital. General practices are randomized to […]
11C-PiB PET assessment of change in fibrillar amyloid-beta load in patients with Alzheimer’s disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study
Rinne, Juha O.,
Brooks, David J.,
Rossor, Martin N.,
Fox, Nick C.,
Bullock, Roger,
Klunk, William E.,
Mathis, Chester A.,
Blennow, Kaj,
Barakos, Jerome,
Okello, Aren A.,
Rodriguez Martinez de Liano, Sofia,
Liu, Enchi,
Koller, Martin,
Gregg, Keith M.,
Schenk, Dale,
Black, Ronald,
Grundman, Michael
Background: Carbon-11-labelled Pittsburgh compound B ((11)C-PiB) PET is a marker of cortical fibrillar amyloid-beta load in vivo. We used (11)C-PiB PET to investigate whether bapineuzumab, a humanised anti-amyloid-beta monoclonal antibody, would reduce cortical fibrillar amyloid-beta load in patients with Alzheimer’s disease.; Methods: Patients with mild-to-moderate Alzheimer’s disease were randomly assigned to receive intravenous bapineuzumab or […]
A randomized pilot clinical trial of the safety of pioglitazone in treatment of patients with Alzheimer disease
Objectives: To evaluate the safety of the peroxisome proliferator-activated receptor gamma agonist pioglitazone in nondiabetic patients with Alzheimer disease (AD) and to explore treatment effect sizes on clinical outcomes.; Design: Double-blind, placebo-controlled randomized controlled trial of 18-month duration.; Setting: Two academic medical center outpatient clinics.; Patients: Nondiabetic patients meeting research criteria for probable AD were […]
Effect of an antioxidant drink on homocysteine levels in Alzheimer’s patients
Morillas-Ruiz, J. M.,
Rubio-Perez, J. M.,
Albaladejo, M. D.,
Zafrilla, P.,
Parra, S.,
Vidal-Guevara, M. L.
Background: A large body of evidence supports a role of oxidative stress in Alzheimer disease (AD) and in cerebrovascular disease. Blood levels of homocysteine may be increased in AD and hyperhomocysteinemia may contribute to disease pathophysiology by vascular and direct neurotoxic mechanisms. Even in the absence of vitamin deficiency, plasma total homocysteine (tHcy) concentration may […]