Hampstead, Benjamin M., Sathian, Krish, Phillips, Pamela A., Amaraneni, Akshay, Delaune, William R., Stringer, Anthony Y.

Objective: To evaluate the efficacy of mnemonic strategy training versus a matched-exposure control condition and to examine the relationship between training-related gains, neuropsychological abilities, and medial temporal lobe volumetrics in patients with amnestic mild cognitive impairment (aMCI) and age-matched healthy controls.; Method: Twenty-three of 45 screened healthy controls and 29 of 42 screened patients with […]

Callahan, Christopher M., Boustani, Malaz A., Schmid, Arlene A., Austrom, Mary G., Miller, Douglas K., Gao, Sujuan, Morris, Carrie S., Vogel, Mickey, Hendrie, Hugh C.

Background: Given the current lack of disease-modifying therapies, it is important to explore new models of longitudinal care for older adults with dementia that focus on improving quality of life and delaying functional decline. In a previous clinical trial, we demonstrated that collaborative care for Alzheimer’s disease reduces patients’ neuropsychiatric symptoms as well as caregiver […]

Zellner, Maria, Babeluk, Rita, Jakobsen, Lene H., Gerner, Christopher, Umlauf, Ellen, Volf, Ivo, Roth, Erich, Kondrup, Jens

Studies investigating the impact of high meat intake on cognition have yielded contradictory results as some show improved cognitive performance, whereas others report an increase of risk factors for dementia. However, few studies were designed to directly assess the effect of a high protein (HP) diet on both cognitive performance and corresponding biochemical parameters. A […]

Kume, Kazumasa, Hanyu, Haruo, Sakurai, Hirofumi, Takada, Yusuke, Onuma, Takeshi, Iwamoto, Toshihiko

Aim: Recent studies have shown that some antihypertensive medications are associated with a significant reduction in the incidence of Alzheimer’s disease (AD). However, it remains uncertain whether antihypertensive drugs may have a preventive effect on cognitive decline in patients with AD. We investigated the effects of telmisartan, an angiotensin II type 1 receptor blocker with […]

Hampstead, Benjamin M., Stringer, Anthony Y., Stilla, Randall F., Giddens, Michelle, Sathian, K.

Learning and memory deficits typify patients with mild cognitive impairment (MCI) and are generally attributed to medial temporal lobe dysfunction. Although the hippocampus is perhaps the most commonly studied neuroanatomical structure in these patients, there have been few attempts to identify rehabilitative interventions that facilitate its functioning. Here, we present results from a randomized, controlled, […]

Anstey, Kaarin J., Bahar-Fuchs, Alex, Herath, Pushpani, Rebok, George W., Cherbuin, Nicolas

Background: Disappointing results from clinical trials of disease-modifying interventions for Alzheimer’s dementia (AD), along with reliable identification of modifiable risk factors in mid life from epidemiological studies, have contributed to calls to invest in risk-reduction interventions. It is also well known that AD-related pathological processes begin more than a decade before the development of clinical […]

Huang, Huei-Ling, Kuo, Li-Min, Chen, Yu-Shu, Liang, Jersey, Huang, Hsiu-Li, Chiu, Yi-Chen, Chen, Sien-Tsong, Sun, Yu, Hsu, Wen-Chuin, Shyu, Yea-Ing L.

Objective: To investigate the effects of an individualized, home-based caregiver-training program for caregivers of elderly patients with dementia and behavioral problems.; Methods: Using a randomized clinical trial in the neurologic clinics of two hospitals and a community care management center in northern Taiwan, we tested an individualized home-based caregiver-training program for managing behavioral problems, with […]