This site uses cookies to measure how you use the website so it can be updated and improved based on your needs and also uses cookies to help remember the notifications you’ve seen, like this one, so that we don’t show them to you again. If you could also tell us a little bit about yourself, this information will help us understand how we can support you better and make this site even easier for you to use and navigate.

Mnemonic strategy training improves memory for object location associations in both healthy elderly and patients with amnestic mild cognitive impairment: a randomized, single-blind study


Hampstead, Benjamin M., Sathian, Krish, Phillips, Pamela A., Amaraneni, Akshay, Delaune, William R., Stringer, Anthony Y.


Neuropsychology, Volume: 26, No.: 3, Pages.: 385-399

Year of Publication



Objective: To evaluate the efficacy of mnemonic strategy training versus a matched-exposure control condition and to examine the relationship between training-related gains, neuropsychological abilities, and medial temporal lobe volumetrics in patients with amnestic mild cognitive impairment (aMCI) and age-matched healthy controls.; Method: Twenty-three of 45 screened healthy controls and 29 of 42 screened patients with aMCI were randomized to mnemonic strategy or matched-exposure groups. Groups were run in parallel, with participants blind to the other intervention. All participants completed five sessions within 2 weeks. Memory testing for object-location associations (OLAs) was performed during sessions one and five and at a 1-month follow-up. During Sessions 2-4, participants received either mnemonic strategy training or a matched number of exposures with corrective feedback for a total of 45 OLAs. Structural magnetic resonance imaging was performed in most participants, and medial temporal lobe volumetrics were acquired.; Results: Twenty-one healthy controls and 28 patients with aMCI were included in data analysis. Mnemonic strategy training was significantly more beneficial than matched exposure immediately after training, p = .006, partial η2 = .16, and at 1 month, p < .001, partial η2 = .35, regardless of diagnostic group (healthy group or aMCI group). Although patients with aMCI demonstrated gains comparable to the healthy control groups, their overall performance generally remained reduced. Mnemonic strategy-related improvement was correlated positively with baseline memory and executive functioning and negatively with inferior lateral ventricle volume in patients with aMCI; no significant relationships were evident in matched-exposure patients.; Conclusion: Mnemonic strategies effectively improve memory for specific content for at least 1 month in patients with aMCI.;

Bibtex Citation

@article{Hampstead_2012, doi = {10.1037/a0027545}, url = {}, year = 2012, publisher = {American Psychological Association ({APA})}, volume = {26}, number = {3}, pages = {385--399}, author = {Benjamin M. Hampstead and Krish Sathian and Pamela A. Phillips and Akshay Amaraneni and William R. Delaune and Anthony Y. Stringer}, title = {Mnemonic strategy training improves memory for object location associations in both healthy elderly and patients with amnestic mild cognitive impairment: A randomized, single-blind study.}, journal = {Neuropsychology} }


aged, aged, 80 and over, aging, association learning, cognitive therapy, complications, cues, etiology, followup studies, humans, magnetic resonance imaging, memory disorders, methods, mild cognitive impairment, neuropsychological tests, pain measurement, pathology, physiology, rehabilitation, semantics, singleblind method, statistics nonparametric, temporal lobe

Countries of Study


Types of Dementia

Mild Cognitive Impairment (MCI)

Types of Study

Randomised Controlled Trial

Type of Outcomes


Type of Interventions

Non-pharmacological Treatment

Non-Pharmaceutical Interventions

Adult safeguarding and abuse detection/prevention