This database contains 40 studies, archived under the term: "sensitivity and specificity"
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Deep learning based imaging data completion for improved brain disease diagnosis
Li, Rongjian,
Zhang, Wenlu,
Suk, Heung-Il,
Wang, Li,
Li, Jiang,
Shen, Dinggang,
Ji, Shuiwang
Combining multi-modality brain data for disease diagnosis commonly leads to improved performance. A challenge in using multimodality data is that the data are commonly incomplete; namely, some modality might be missing for some subjects. In this work, we proposed a deep learning based framework for estimating multi-modality imaging data. Our method takes the form of […]
Prediction of dementia in primary care patients
Jessen, Frank,
Wiese, Birgitt,
Bickel, Horst,
Eiffländer-Gorfer, Sandra,
Fuchs, Angela,
Kaduszkiewicz, Hanna,
Köhler, Mirjam,
Luck, Tobias,
Mösch, Edelgard,
Pentzek, Michael,
Riedel-Heller, Steffi G.,
Wagner, Michael,
Weyerer, Siegfried,
Maier, Wolfgang,
van den Bussche, Hendrik
Background: Current approaches for AD prediction are based on biomarkers, which are however of restricted availability in primary care. AD prediction tools for primary care are therefore needed. We present a prediction score based on information that can be obtained in the primary care setting.; Methodology/principal Findings: We performed a longitudinal cohort study in 3.055 […]
Altered microstructure in corticospinal tract in idiopathic normal pressure hydrocephalus: comparison with Alzheimer disease and Parkinson disease with dementia
Hattori, T.,
Yuasa, T.,
Aoki, S.,
Sato, R.,
Sawaura, H.,
Mori, T.,
Mizusawa, H.
Background and Purpose: Previous neuropathologic studies in chronic hydrocephalus have suggested the presence of white matter damage, presumably from mechanical pressure due to ventricular enlargement and metabolic derangement. This study aimed to investigate the diffusional properties of the CST in patients with iNPH by using DTI and to determine whether this method could be used […]
A sensitivity comparison of clinical tests for postural instability in patients with Huntington’s disease
Brožová, Hana,
Štochl, Jan,
Klempíř, Jiří,
Kucharík, Martin,
Růžička, Evžen,
Roth, Jan
Falls are a common complication in Huntington’s disease (HD) and detection of postural instability (PI) may be useful for identifying patients who are at risk of falls. The aim of our study was to find the most sensitive clinical test for PI in patients with HD and to correlate PI with the other symptoms. 20 […]
Predicting decline in mild cognitive impairment: A prospective cognitive study
Objective: The primary aim of this study was to identify cognitive tests that differentiate between persons with mild cognitive impairment (MCI) who later develop cognitive decline and those who remain stable. Method: This study used a prospective longitudinal design. One hundred twenty-two older adults with single-domain or multiple-domain amnestic MCI were recruited from memory clinics. […]
Hostility and change in cognitive function over time in older blacks and whites
Barnes, Lisa L.,
Mendes de Leon, Carlos F.,
Bienias, Julia L.,
Wilson, Robert S.,
Everson-Rose, Susan A.,
Evans, Denis A.
Objective: To test whether the level of hostility predicted the rate of cognitive decline in a community of older blacks and whites and whether the association varied as a function of race.; Methods: Over 4800 persons from a defined community in Chicago completed up to three structured interviews at approximately 3 year intervals over a […]
Prediction of amyloid-β pathology in amnestic mild cognitive impairment with neuropsychological tests
Bahar-Fuchs, Alex,
Villemagne, Victor,
Ong, Kevin,
Chetélat, Gaël,
Lamb, Fiona,
Reininger, Cornelia B.,
Woodward, Michael,
Rowe, Christopher C.
Assessment of disease biomarkers, particularly the in vivo assessment of amyloid-β (Aβ) burden with positron emission tomography (PET), is gradually becoming central to the diagnosis of mild cognitive impairment (MCI) due to Alzheimer’s disease (AD). However, the incorporation of biomarker evidence to the diagnostic process is currently restricted mainly to research settings. The identification of […]