This database contains 85 studies, archived under the term: "risk factors"
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Increased pulse pressure linked to dementia: further results from the Hypertension in the Very Elderly Trial – HYVET
Peters, Ruth,
Beckett, Nigel,
Fagard, Robert,
Thijs, Lutgarde,
Wang, Ji-Guang,
Forette, Francoise,
Pereira, Lisa,
Fletcher, Astrid,
Bulpitt, Christopher
Objectives: High blood pressure (BP) has been associated with increased risk of dementia. Concerns have been raised about lowering BP too far in the very elderly and thereby increasing risk. There is some evidence to suggest a potential ‘J’-shaped relationship between DBP and risk of cognitive impairment. This was investigated using data from the HYpertension […]
Isolated theory of mind deficits and risk for frontotemporal dementia: A longitudinal pilot study
Pardini, M.,
Emberti Gialloreti, L.,
Mascolo, M.,
Benassi, F.,
Abate, L.,
Guida, S.,
Viani, E.,
Dal Monte, O.,
Schintu, S.,
Krueger, F.,
Cocito, L.
Objective: Recent data suggest that theory of mind (ToM) deficits represent an early symptom of the behavioural variant of frontotemporal dementia (bvFTD). However, longitudinal data on the natural history of subjects presenting with isolated ToM deficits are lacking. The aim of the study was to verify if isolated ToM deficits represent an at-risk state for […]
Cognitive function, social integration and mortality in a U.S. national cohort study of older adults
Background: Prior research suggests an interaction between social networks and Alzheimer’s disease pathology and cognitive function, all predictors of survival in the elderly. We test the hypotheses that both social integration and cognitive function are independently associated with subsequent mortality and there is an interaction between social integration and cognitive function as related to mortality […]
Plasma free choline, betaine and cognitive performance: the Hordaland Health Study
Nurk, Eha,
Refsum, Helga,
Bjelland, Ingvar,
Drevon, Christian A.,
Tell, Grethe S.,
Ueland, Per M.,
Vollset, Stein E.,
Engedal, Knut,
Nygaard, Harald A.,
Smith, David A.
Choline and betaine are nutrients involved in one-carbon metabolism. Choline is essential for neurodevelopment and brain function. We studied the associations between cognitive function and plasma concentrations of free choline and betaine. In a cross-sectional study, 2195 subjects (55 % women), aged 70-74 years, underwent extensive cognitive testing including the Kendrick Object Learning Test (KOLT), […]
Long-term metformin usage and cognitive function among older adults with diabetes
Ng, Tze Pin,
Feng, Liang,
Yap, Keng Bee,
Lee, Tih Shih,
Tan, Chay Hoon,
Winblad, Bengt
Evidence strongly supports the important role of insulin resistance in cognitive decline and dementia and suggests that insulin sensitizers may protect against cognitive decline in diabetic and pre-diabetic individuals. Inconclusive results have been reported in clinical trials of rosiglitazone, an insulin sensitizer that also increases cardiovascular mortality risks. No study has yet reported a protective […]
The effect of Baroque music on behavioural disturbances in patients with dementia
Nair, Balakrishnan Kichu,
Heim, Christian,
Krishnan, Chitra,
D'Este, Catherine,
Marley, John,
Attia, John
Aim: To study the effect of Baroque music in people with dementia.; Methods: Patients in a multicultural dementia-specific aged care facility were subjected to Baroque music in a cross-over study.; Results: There were significantly more behavioural disturbances during the weeks when Baroque music was played compared to control periods (0.2 more episodes per week, P […]
Optimal blood pressure for cognitive function: findings from an elderly African-American cohort study
Liu, Hai,
Gao, Sujuan,
Hall, Kathleen S.,
Unverzagt, Frederick W.,
Lane, Kathleen A.,
Callahan, Christopher M.,
Hendrie, Hugh C.
Objectives: To report the results from a prospective cohort study on the association between blood pressure (BP) and cognitive function in elderly African Americans.; Design: Prospective cohort study conducted from 1997 to 2009.; Setting: Community-based study in Indianapolis.; Participants: African Americans aged 65 years or older (N = 3,145).; Measurements: At each assessment, participant cognitive […]
Irritable bowel syndrome correlates with increased risk of Parkinson’s disease in Taiwan
This study investigated whether an association exists between irritable bowel syndrome (IBS) and the risk of Parkinson’s disease. This is a retrospective cohort study using the dataset of the Taiwan National Health Insurance Program from 2000 to 2010. We identified 23,875 patients (aged 20 years or older) with newly diagnosed IBS as the IBS group […]
A home‐based training program improves Taiwanese family caregivers’ quality of life and decreases their risk for depression: A randomized controlled trial
Kuo, Li-Min,
Huang, Huei-Ling,
Huang, Hsiu-Li,
Liang, Jersey,
Chiu, Yi-Chen,
Chen, Sien-Tsong,
Kwok, Yam-Ting,
Hsu, Wen-Chuin,
Shyu, Yea-Ing L.
Objectives: Little is known about the longitudinal effects of training programs on family caregivers’ health-related quality of life (HRQoL) and depressive symptoms over time. Therefore, the purpose of this study was to examine the effects of a home-based caregiver training program on HRQoL and depressive symptoms for family caregivers of older persons with dementia. Methods: […]
A home-based training program improves Taiwanese family caregivers’ quality of life and decreases their risk for depression: a randomized controlled trial
Kuo, Li-Min,
Huang, Huei-Ling,
Huang, Hsiu-Li,
Liang, Jersey,
Chiu, Yi-Chen,
Chen, Sien-Tsong,
Kwok, Yam-Ting,
Hsu, Wen-Chuin,
Shyu, Yea-Ing L.
Objectives: Little is known about the longitudinal effects of training programs on family caregivers’ health-related quality of life (HRQoL) and depressive symptoms over time. Therefore, the purpose of this study was to examine the effects of a home-based caregiver training program on HRQoL and depressive symptoms for family caregivers of older persons with dementia.; Methods: […]