Schmitt, Frederick A., Farlow, Martin R., Meng, Xiangyi, Tekin, Sibel, Olin, Jason T.

Background and Objective: Rivastigmine is approved in the USA for the treatment of mild to moderate Alzheimer’s disease and Parkinson’s disease dementia (PDD). Executive function (EF) deficits are a core symptom of PDD. The current objective was to investigate the effects of rivastigmine capsules versus placebo on EF in PDD, focusing on secondary outcome measures […]

Matsuda, Osamu, Shido, Emi, Hashikai, Ayako, Shibuya, Haruka, Kouno, Mitsue, Hara, Chizuko, Saito, Masahiko

Background: Acetylcholinesterase inhibitors (i.e. donepezil) are known to benefit Alzheimer’s disease (AD) patients. However, the combined effects of acetylcholinesterase and cognitive stimulation therapy (CST) are still debated. The present study examined their combined effects on the progression of cognitive decline in AD.; Methods: The present study was a non-randomized controlled study and included two groups […]

Cooke, Marie L., Moyle, Wendy, Shum, David H.K., Harrison, Scott D., Murfield, Jenny E.

Objectives: This study, as part of a larger programme of research, sought to investigate the effect that participation in a 40-min live group music programme, involving facilitated engagement with song-singing and listening, three times a week for eight weeks, had on agitation and anxiety in older people with dementia.; Methods: A randomized cross-over design, with […]

Weintraub, S., Mesulam, M.-M., Wieneke, C., Rademaker, A., Rogalski, E. J., Thompson, C. K.

Primary progressive aphasia (PPA) is a clinical dementia syndrome with early symptoms of language dysfunction. Postmortem findings are varied and include Alzheimer disease and frontotemporal lobar degeneration (FTLD), both tauopathies and TAR DNA binding protein (TDP-43) proteinopathies. Clinical-pathological correlations in PPA are complex but the presence in the clinical profile of agrammatism has a high […]

Moyle, Wendy, Cooke, Marie, Beattie, Elizabeth, Jones, Cindy, Klein, Barbara, Cook, Glenda, Gray, Chrystal

This pilot study aimed to compare the effect of companion robots (PARO) to participation in an interactive reading group on emotions in people living with moderate to severe dementia in a residential care setting. A randomized crossover design, with PARO and reading control groups, was used. Eighteen residents with mid- to late-stage dementia from one […]

Kawashima, Ryuta

The purpose of this study was to examine the beneficial effects of a new cognitive intervention program designed for the care and prevention of dementia, namely Learning Therapy. The training program used systematized basic problems in arithmetic and Japanese language as training tasks. In study 1, 16 individuals in the experimental group and 16 in […]

Eggermont, Laura H.P., Knol, Dirk L., Hol, Elly M., Swaab, Dick F., Scherder, Erik J.A.

Background: Physical activity such as walking may exert a positive impact on cognition and behaviour in older persons with dementia, but due to the frailty of the population it may be worthwhile to consider other motor activities as well.; Objective: Examining the effects of hand motor activity on cognition, mood and the rest-activity rhythm in […]